Evidence map›Paper›PMID 39489718›Full record

ArticleMacromolecular bioscience2025

Surface Coating of ZIF-8 Nanoparticles with Polyacrylic Acid: A Facile Approach to Enhance Chemical Stability for Biomedical Applications.

Setsuko Yamane, Abdul Hadi Bin Yusri, Po-Yu Chen, André J van der Vlies, Amira Ben Mabrouk, Isabelle Fetzer, Urara Hasegawa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Setsuko YamaneDepartment of Materials Science and Engineering, The Pennsylvania State University, Steidle Building, 80 Pollock Road, University Park, PA, 16802, USA.
Abdul Hadi Bin YusriDepartment of Materials Science and Engineering, The Pennsylvania State University, Steidle Building, 80 Pollock Road, University Park, PA, 16802, USA.
Po-Yu ChenDepartment of Materials Science and Engineering, The Pennsylvania State University, Steidle Building, 80 Pollock Road, University Park, PA, 16802, USA.
André J van der VliesDepartment of Materials Science and Engineering, The Pennsylvania State University, Steidle Building, 80 Pollock Road, University Park, PA, 16802, USA.
Amira Ben MabroukDepartment of Materials Science and Engineering, The Pennsylvania State University, Steidle Building, 80 Pollock Road, University Park, PA, 16802, USA.
Isabelle FetzerDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Urara HasegawaDepartment of Materials Science and Engineering, The Pennsylvania State University, Steidle Building, 80 Pollock Road, University Park, PA, 16802, USA.ORCID 0000-0002-4189-7630

Funding

Division of Chemical, Bioengineering, Environmental, and Transport Systems 2102848National Institute of Technology Faculty Research Abroad Program
6 · The paper itself

Abstract

Nanoparticles of zeolitic imidazole framework-8 (ZIF-8 NPs), which are the subclass of metal-organic frameworks consisting of Zn ion and 2-methylimidazole, have been identified as promising drug carriers since their large microporous structure is suited for encapsulating hydrophobic drug molecules. However, one of the limitations of ZIF-8 NPs is their low stability in physiological solutions, especially in the presence of water and phosphate anions. These molecules can interact with the coordinatively unsaturated Zn sites at the external surface to induce the degradation of ZIF-8 NPs. In this study, herein a facile approach is reported to enhance the chemical stability of ZIF-8 NPs by surface coating with polyacrylic acid (PAA). The PAA-coated ZIF-8 (PAA-ZIF-8) NPs are prepared by mixing ZIF-8 NPs and PAA in water. PAA coating inhibits the degradation of ZIF-8 NPs in water as well as phosphate-buffered saline over 6 days, which seems to be due to the coordination of carboxyl groups of PAA to the reactive Zn sites. Furthermore, the PAA-ZIF-8 NPs loaded with the anticancer drug doxorubicin (Dox) show cytotoxicity in human colon cancer cells. These results clearly show the feasibility of the PAA coating approach to improve the chemical stability of ZIF-8 NPs without impairing their drug delivery capability.

Indexed as

Acrylic ResinsCoated Materials, BiocompatibleMetal-Organic FrameworksNanoparticlesZeolitesDoxorubicinDrug CarriersHumansImidazolesSurface PropertiesAcrylic Resinscarbopol 940Coated Materials, BiocompatibleDoxorubicinDrug CarriersImidazolesMetal-Organic FrameworksZeolitesZIF-8 metal-organic frameworkchemical stabilitydrug deliverypolyacrylic acidsurface modificationzeolitic imidazole framework

Identifiers

PMID39489718
PMCPMC11827546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.