Evidence map›Paper›PMID 39489405›Full record

ArticleAlcohol (Fayetteville, N.Y.)2025

Evaluating a 30-day alcohol abstinence challenge in heavy-drinking individuals with and without chronic pain: Feasibility, safety, and perceived benefits.

Dokyoung S You, Maisa S Ziadni, Noel Vest, Nareh Megerdichian, Tara Maronesy, Ralph J Castro, Beth D Darnall, Sean C Mackey, Keith Humphreys

Abstract read
In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dokyoung S YouDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA; University of Oklahoma Health Promotion Research Center - Tulsa, Dept. of Family and Community Medicine, 4502 E. 41(st) Street, Tulsa, OK, USA. Electronic address: dyou@ouhsc.edu.
Maisa S ZiadniDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Noel VestBoston University School of Public Health, Department of Community Health Sciences, 801 Massachusetts Avenue, Boston, MA 02118, USA.
Nareh MegerdichianDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Tara MaronesyDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Ralph J CastroOffice of Substance Use Programs, Education & Resources, Stanford University, USA.
Beth D DarnallDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Sean C MackeyDivision of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Palo Alto, CA, USA.
Keith HumphreysDepartment: Psych/Public Mental Health & Population Sciences, Stanford University, USA; Department of Psychiatry and the Behavioral Sciences, Stanford University, USA.

Funding

Western States Node of the National Drug Abuse Treatment Clinical Trials Network (TMS for CUD) UG1DA015815 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Keith N. Humphreys, Philip Todd Korthuis · 2015 to 2026
$24.6M
Research and Mentoring in Innovative Patient Oriented Pain and Opioid ScienceK24DA053564 · NIDA · STANFORD UNIVERSITY · PI Beth Denise Darnall · 2021 to 2026
$1.0M
Collegiate recovery programming in the U.S.: An implementation science and mixed methods studyK01DA053391 · NIDA · STANFORD UNIVERSITY · PI Noel Adam Vest · 2022 to 2026
$882k
Single Session Pain Catastrophizing Class: Efficacy & Mechanisms for Reducing Opioid Use Among Chronic Pain PatientsK23DA047473 · NIDA · STANFORD UNIVERSITY · PI ZIADNI, MAISA · 2019 to 2023
$796k
Effect of pain catastrophizing on prescription opioid cravingK23DA048972 · NIDA · STANFORD UNIVERSITY · PI YOU, DOKYOUNG SOPHIA · 2019 to 2023
$758k
HSRD VA I01 HX002714NIDA NIH HHS K01 DA053391NIDA NIH HHS K23 DA047473NIDA NIH HHS K23 DA048972NIDA NIH HHS K24 DA053564NIDA NIH HHS L30 DA056944NIDA NIH HHS UG1 DA015815
6 · The paper itself

Abstract

introductionTo combat high-risk alcohol consumption, we introduced a 30-day alcohol abstinence challenge targeted at heavy drinkers with and without chronic pain. Our study aimed to assess the challenge's feasibility and safety and to explore its perceived benefits. Our exploratory aim was to identify participants' coping strategies during the challenge.

methodsOur single-arm study recruited heavy drinkers from a pain clinic and a university setting (n = 34, 64.7% chronic pain). Participants underwent a modified community-based 30-day challenge, which included motivational interviewing, an individualized start date, and weekly phone check-ins.

resultsWe found the 30-day challenge was feasible and safe; 72.3% of eligible heavy drinkers participated in the challenge with no serious adverse events. Most challengers (94.1%) reported some benefit from the challenge, which included improvements in alcohol withdrawal symptoms, sleep, and alcohol abstinence self-efficacy, but not in pain. We identified 25 perceived benefits and 21 coping strategies.

conclusionOur study confirms that a 30-day alcohol abstinence challenge is a feasible and safe intervention for heavy drinkers with and without chronic pain, yielding notable health benefits. The challenge also facilitated the development of effective coping strategies. Future studies should explore the long-term benefits of such interventions in broader outpatient settings.

Indexed as

Alcohol AbstinenceAlcohol DrinkingAlcoholismChronic PainAdaptation, PsychologicalAdultFeasibility StudiesFemaleHumansMaleMiddle AgedMotivational InterviewingYoung AdultAlcohol Abstinence ChallengeChronic PainQualitative AnalysisQuantitative AnalysisSelf-Efficacy

Identifiers

PMID39489405
PMCPMC11757067

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.