ArticleArquivos de neuro-psiquiatria2024
Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients.
Article in Arquivos de neuro-psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.
objectiveTo analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).
methodsThe sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.
resultsThe lowest total hippocampal volume (
conclusionThe current findings present evidence of the relationship between hippocampal volume and LCT in patients with AD and MCI.
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