Evidence map›Paper›PMID 39488941›Full record

ArticleDrug and alcohol dependence2024

Associations of discomfort intolerance, discomfort avoidance, and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for opioid use disorder.

Danielle F Haley, Michael D Stein, Sally Bendiks, Skylar Karzhevsky, Claire Pierce, Ana Dunn, Debra S Herman, Bradley Anderson, Risa B Weisberg

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03698669 (Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03698669 nacompletednot on this map

Treating Chronic Pain in Buprenorphine Patients in Primary Care Settings

TypeinterventionalSponsorBoston UniversityRan2019 to 2024Enrolled163ConditionsOpioid-Related DisordersArmsTreating Opioid Patients' Pain and Sadness (TOPPS), Health Education (HE)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Danielle F HaleyDepartment of Community Health Sciences, Boston University School of Public Health, 801 Massachusetts Avenue, Boston, MA, USA. Electronic address: dfhaley@bu.edu.
Michael D SteinDepartment of Health Law, Policy & Management, Boston University School of Public Health, Health, 715 Albany Street, Boston, MA 02118, USA; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA. Electronic address: mdstein@bu.edu.
Sally BendiksDepartment of Medicine, Section of General Internal Medicine, Boston Medical Center, Clinical Addiction Research and Education (CARE), 801 Massachusetts Avenue, 2nd Floor, Boston, MA 02118, USA. Electronic address: sally.bendiks@bmc.org.
Skylar KarzhevskyDepartment of Health Law, Policy & Management, Boston University School of Public Health, Health, 715 Albany Street, Boston, MA 02118, USA. Electronic address: skylarak@bu.edu.
Claire PierceDepartment of Health Law, Policy & Management, Boston University School of Public Health, Health, 715 Albany Street, Boston, MA 02118, USA. Electronic address: cmpierce@bu.edu.
Ana DunnDepartment of Behavioral Medicine and Addictions Research, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA. Electronic address: adunn@butler.org.
Debra S HermanDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA; Department of Behavioral Medicine and Addictions Research, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA. Electronic address: debra_herman@brown.edu.
Bradley AndersonDepartment of Behavioral Medicine and Addictions Research, Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA. Electronic address: bjaskis@icloud.com.
Risa B WeisbergDepartment of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, 720 Harrison Avenue, 9th Floor, Boston, MA 02118, USA; Department of Family Medicine, Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA; RealizedCare, 1690 Ring Road #110, Elizabethtown, KY 42701, USA. Electronic address: risaw@bu.edu.

Funding

Treating Chronic Pain in Buprenorphine Patients in Primary Care SettingsR01DA045695 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI STEIN, MICHAEL D, WEISBERG, RISA B · 2019 to 2023
$3.7M
Quantifying health policy impacts on substance use and treatment among women with and at risk for HIV: a longitudinal multilevel analysis using the Women's Interagency HIV StudyK01DA046307 · NIDA · NORTHEASTERN UNIVERSITY · PI HALEY, DANIELLE FRANCES · 2018 to 2022
$865k
NIDA NIH HHS K01 DA046307NIDA NIH HHS R01 DA045695
6 · The paper itself

Abstract

backgroundChronic pain and non-prescribed substance use are associated with lower retention in opioid use disorder (OUD) treatment. We examined the associations of perceived capacity to tolerate uncomfortable physical sensations (discomfort intolerance and discomfort avoidance) and cannabis and alcohol use among persons with chronic pain receiving prescription buprenorphine for OUD.

methodsThis study utilizes baseline data from 163 persons with chronic pain receiving prescription buprenorphine for OUD enrolled in the Treating Opioid use, Persistent Pain, and Sadness (TOPPS) intervention trial. We used negative-binomial regression models, adjusted for age, education, gender, race/ethnicity, pain interference, depression, generalized anxiety disorder, and average cigarettes smoked/day to estimate the associations of discomfort tolerance and discomfort avoidance with frequency of cannabis and alcohol use.

resultsParticipants (n=163) were on average 45 years old (standard deviation=10.6) and predominantly White (86 %, n=141). Forty-one percent (n=66) used cannabis and 24 % (n=30) used alcohol use in the past 30 days. In adjusted models, discomfort intolerance was positively associated with days of cannabis use (IRR = 1.11, p =.016) and days of alcohol use (IRR = 1.14, p =.022). Discomfort avoidance was not associated with cannabis or alcohol use.

conclusionIndividuals with chronic pain receiving prescribed buprenorphine for treatment of OUD with lower tolerance for physical discomfort may augment pain management with cannabis and alcohol. Given the intersections between substance use and retention in care for OUD, future work should extend this preliminary work by exploring these relationships over time and in experimental settings. Clinical Trial # NCT03698669.

Indexed as

Alcohol DrinkingBuprenorphineChronic PainOpioid-Related DisordersAdultAnalgesics, OpioidAvoidance LearningFemaleHumansMaleMiddle AgedOpiate Substitution TreatmentRandomized Controlled Trials as TopicAnalgesics, OpioidBuprenorphineBuprenorphineCannabisDiscomfort intolerancePain

Identifiers

PMID39488941
PMCPMC11588539

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.