ArticleCell reports2024
An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy.
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In one paragraph
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
20 citing papers in PubMed.
- Mechanisms of systemic immune modulation in tumor development: Interactions across lymph nodes, bone marrow, and blood.Cancer metastasis reviews · 2026Review
- Hepatic fibrosis extracellular matrix stiffness induces abnormal maturation of dendritic cell via AMPK inhibition-mediated cholesterol accumulation.Materials today. Bio · 2026Article
- Cytokine-independent activation of STAT5 promotes the persistence and function of CD4Molecular therapy. Advances · 2026Article
- Receptor-tethered orthogonal IL-2 enhances regulatory T cell therapy.The Journal of experimental medicine · 2026Article
- Regulatory T cell induction strategies and applications in the treatment of immune and non-immune diseases.Signal transduction and targeted therapy · 2026Review
- Leveraging multimodal cancer immunotherapy to amplify the efficacy of oncolytic viruses.Experimental hematology & oncology · 2026Review
- IL-2 mutein promotes antigen-specific transplant acceptance in mice through expansion of ST2Nature communications · 2026Article
- Next-Generation regulatory T cell therapies: Translational considerations for inflammatory bowel disease.Human immunology · 2026Review
- Defects in CD8bioRxiv : the preprint server for biology · 2026Article
- CAR Treg therapies for neurodegenerative diseases.iScience · 2026Review
- Activation and lineage specific Lag3 expression dynamics in T cells.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Divergent effects of a Treg-selective IL-2 mutein on influenza-specific T cell responses.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Correlation and combined predictive value analysis of serum IL-6 and IL-10 levels with tumor progression in patients with cervical cancer.European journal of medical research · 2026Article
- An imbalance between CD80 and CD86 levels and CD4 regulatory T cell number and transendocytosis function exists in the liver in autoimmune hepatitis.Clinical and experimental immunology · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Inborn errors of regulatory T-cell differentiation and function.The Journal of allergy and clinical immunology · 2025Review
- HPV-Independent Cervical Cancer-A New Challenge of Modern Oncology.International journal of molecular sciences · 2025Review
- Divergent effects of a Treg-selective IL-2 mutein on Influenza specific T cell responses.bioRxiv : the preprint server for biology · 2025Article
- Pharmacotherapeutic strategies to promote regulatory T cell function in autoimmunity.Current opinion in immunology · 2025Review
- ZFP36-family RNA-binding proteins in regulatory T cells reinforce immune homeostasis.Nature communications · 2025Article
Corrections and comments
- Update of
Authors and funding
9 authors.
Braxton L JamisonCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98126, USA.
Matthew LawranceCenter for Systems Immunology, Benaroya Research Institute, Seattle, WA 98126, USA.
Chun Jing WangInstitute of Immunity & Transplantation, Pears Building, University College London Division of Infection & Immunity, London NW3 2PP, UK.
Hannah A DeBergCenter for Systems Immunology, Benaroya Research Institute, Seattle, WA 98126, USA.
Lauren J ZieglerCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98126, USA.
David M SansomInstitute of Immunity & Transplantation, Pears Building, University College London Division of Infection & Immunity, London NW3 2PP, UK.
Marc A GavinCenter for Translational Immunology, Benaroya Research Institute, Seattle, WA 98126, USA.
Lucy S K WalkerInstitute of Immunity & Transplantation, Pears Building, University College London Division of Infection & Immunity, London NW3 2PP, UK.
Daniel J CampbellCenter for Fundamental Immunology, Benaroya Research Institute, Seattle, WA 98126, USA; Department of Immunology, University of Washington School of Medicine, Seattle, WA 981098, USA. Electronic address: dcampbell@benaroyaresearch.org.
Funding
Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune toleranceR01AI154773 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI CAMPBELL, DANIEL J, WELLS, ANDREW D · 2021 to 2025
$3.8MTargeting the IL-2/regulatory T cell axis for autoimmune disease prevention in realistic animal modelsR01AI136475 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J, ZIEGLER, STEVEN F · 2018 to 2022
$3.4MMechanisms of Il-2-mediated immune toleranceR21AI172140 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI CAMPBELL, DANIEL J · 2023 to 2024
$477kMedical Research Council MR/N001435/1NIAID NIH HHS R01 AI136475NIAID NIH HHS R01 AI154773NIAID NIH HHS R21 AI172140
Abstract
Interleukin-2 (IL-2) variants with increased CD25 dependence that selectively expand Foxp3
Indexed as
Clonal AnergyCTLA-4 AntigenDendritic CellsInterleukin-10Interleukin-2Mice, Inbred NODT-Lymphocytes, RegulatoryAnimalsCell ProliferationMiceCTLA-4 AntigenInterleukin-10Interleukin-2anergyCP: ImmunologyCTLA-4IL-2regulatory T cellstolerance
Identifiers
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.