Evidence map›Paper›PMID 39488791›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

A Turbo-Charging System-Like Contrast Agent for MRI-Guided STING Pathway-Activated Cancer Immunotherapy.

Bin Ren, Sihua Yan, Zongheng Li, Ya Huang, Haobin Cai, Jing Yang, Qingdeng Fan, Chunmei Chen, Fanchao Que, Guochao Wu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bin RenSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Sihua YanDepartment of Breast Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
Zongheng LiSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Ya HuangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Haobin CaiSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Jing YangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Qingdeng FanSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Chunmei ChenSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Fanchao QueSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Guochao WuSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Lin HuangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Ruilong ZhouSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Jiaoyang ZhuSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Chenggong YanMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Gang LiuSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Zheyu ShenSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.ORCID 0000-0002-0350-375X
Shipeng NingDepartment of Breast Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.

Funding

Guangdong Provincial Natural Science Foundation of China 2024A1515012639Guangzhou Key Research and Development Program of China 202103000094National Natural Science Foundation of China 32271374National Natural Science Foundation of China 82303797National Natural Science Foundation of China 82473348
6 · The paper itself

Abstract

To overcome the problems of Gd-based contrast agents (GBCAs) (nephrotoxicity and brain deposition) and stimulator of interferon genes (STING) agonists (poor stability, low delivery efficiency, and potential toxicity), in this study, a Turbo-charging system-like GBCA is designed and constructed for magnetic resonance imaging (MRI) guided STING pathway-activated cancer immunotherapy. Poly(acrylic acid) (PAA) is used to coordinate with Gd

Indexed as

Contrast MediaImmunotherapyMagnetic Resonance ImagingAnimalsCell Line, TumorDisease Models, AnimalGadoliniumHumansMembrane ProteinsMiceNanoparticlesNeoplasmsContrast MediaGadoliniumMembrane Proteinscancer immunotherapyGd‐based contrast agents (GBCAs)magnetic resonance imaging (MRI)stimulator of interferon genes (STING)turbo‐charging system‐like contrast agent (Turbo S)

Identifiers

PMID39488791
PMCPMC11714149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.