Evidence map›Paper›PMID 39488768›Full record

ArticleThe journal of allergy and clinical immunology. In practice2024

An International Delphi Consensus on the Management of Pollen-Food Allergy Syndrome: A Work Group Report of the AAAAI Adverse Reactions to Foods Committee.

Taha Al-Shaikhly, Amanda Cox, Anna Nowak-Wegrzyn, Antonella Cianferoni, Constance Katelaris, Didier G Ebo, George N Konstantinou, Hannelore Brucker, Hyeon-Jong Yang, Jennifer L P Protudjer and 14 more

Abstract readConsensus Statement
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Dragon Fruit Allergy With Cross-Reactivity toCase reports in immunology · 2026
    Article
  5. Pollen-Food Allergy Syndrome in China: Current Knowledge and Future Research Needs.International archives of allergy and immunology · 2026
    Review
  6. Article
  7. [Pollen-food allergy syndrome: association between allergen cross-reactivity and symptom severity].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Taha Al-ShaikhlySection of Allergy, Asthma & Immunology, Department of Medicine, Penn State College of Medicine, Hershey, Pa. Electronic address: talshaikhly@pennstatehealth.psu.edu.
Amanda CoxDepartment of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.
Anna Nowak-WegrzynDepartment of Pediatrics, Hassenfeld Children's Hospital, NYU R. Grossman School of Medicine, New York, NY; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
Antonella CianferoniDivision of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, Pa.
Constance KatelarisImmunology and Allergy Unit, Department of Medicine, Campbelltown Hospital and Western Sydney University, Sydney, New South Wales, Australia.
Didier G EboUniversity of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and the Infla-Med Centre of Excellence, Antwerp (Belgium) and Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp, Belgium; Department of Immunology and Allergology, AZ Jan Palfijn Gent, Ghent, Belgium.
George N KonstantinouDepartment of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece.
Hannelore BruckerSouthdale Allergy and Asthma Clinic, Minneapolis, Minn.
Hyeon-Jong YangDepartment of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.
Jennifer L P ProtudjerDepartment of Pediatrics and Child Health, University of Manitoba, Winnipeg, Man, Canada; Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
José Laerte BoechatBasic and Clinical Immunology Unit and CINTESIS@RISE, Faculty of Medicine, University of Porto, Porto, Portugal.
Joyce E YuDivision of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Irving Medical Center, New York, NY.
Julie WangDepartment of Pediatrics, Division of Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY.
Karen S Hsu BlatmanSection of Allergy and Clinical Immunology, Department of Medicine, Dartmouth Hitchcock Medical Center, Geisel School of Medicine, Lebanon, NH.
Lukasz BlazowskiDepartment of Allergology and Pulmonology, National Research Institute of Tuberculosis and Lung Diseases, Rabka-Zdroj, Poland; Department of Pathophysiology, Institute of Medical Sciences of Rzeszow University, Rzeszow, Poland.
Mahesh Padukudru AnandDepartment of Respiratory Medicine, JSS Medical College, JSSAHER, Mysore, Karnataka, India.
Manish RameshAlbert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY.
Maria J TorresAllergy Clinical Unit, Department of Medicine and Dermatology, Hospital Regional Universitario de Málaga-UMA-IBIMA, Málaga, Spain.
Mark HolbreichAllergy and Asthma Consultants, Indianapolis, Ind.
Richard GoodmanDepartment of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Neb.
Richard L WassermanDepartment of Pediatrics, Medical City Children's Hospital, Dallas, Texas.
Russell HoppDepartment of Pediatrics, University of Nebraska Medical Center, Omaha, Neb.
Sakura SatoClinical Research Center for Allergy and Rheumatology, NHO Sagamihara National Hospital, Kanagawa, Japan.
Isabel SkypalaRoyal Brompton & Harefield Hospitals, part of Guys & St. Thomas National Health Services (NHS) Foundation Trust, London, UK.

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
A novel use of web-based software to efficiently triage pre-surgical patients basR44TR000045 · NCATS · MEDSLEUTH, INC. · PI KALAMAS, ALICIA GRUBER · 2012 to 2012
$546k
NCATS NIH HHS R44 TR000045NCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

backgroundPollen-food allergy syndrome (PFAS) is common among patients with allergic rhinitis. Treatment recommendations for patients with PFAS remain variable.

objectiveTo develop consensus recommendation statements for managing patients with PFAS.

methodsAn international panel of allergists, researchers, and nutritionists with an interest in PFAS from 25 different institutions across 11 countries convened and a list of statements was written by 3 authors. The RAND/University of California Los Angeles methodology was adopted to establish consensus on the statements.

resultsAfter 2 Delphi rounds, a consensus was reached on 14 statements. The panel agreed that patients with PFAS would benefit from counseling on the nature and basis of PFAS and the rare chance of more severe systemic reactions and their recognition. The panel agreed on avoiding the raw food responsible for the index reaction, but not potentially cross-reactive fruits/vegetables based on the responsible food of the index reaction. Epinephrine autoinjectors should be recommended for patients with PFAS who experienced severe symptoms (beyond the oropharynx) or for patients considered at risk for severe reactions. The panel agreed that the benefit of allergen immunotherapy remains unclear and that PFAS should not be considered the primary indication for such intervention.

conclusionsWe developed consensus statements regarding counselling patients about the nature and severity of PFAS, potential risk factors, dietary avoidance, epinephrine autoinjector prescription, and allergen immunotherapy consideration for patients with PFAS.

Indexed as

ConsensusDelphi TechniqueFood HypersensitivityRhinitis, Allergic, SeasonalAllergensDesensitization, ImmunologicEpinephrineHumansPollenSyndromeAllergensEpinephrineDelphi consensusOASOral allergy syndromePFASPFAS managementPollen-food allergy syndrome

Identifiers

PMID39488768
PMCPMC11625607

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.