Evidence map›Paper›PMID 39488662›Full record

ArticleLeukemia2024

Transcriptional regulatory program controlled by MYB in T-cell acute lymphoblastic leukemia.

Xiaoman Shao, Rui Yokomori, Jolynn Zu Lin Ong, Haoqing Shen, Dennis Kappei, Leilei Chen, Allen Eng Juh Yeoh, Shi Hao Tan, Takaomi Sanda

Abstract read
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In one paragraph

Article in Leukemia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoman Shao *Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-3285-1892
Rui Yokomori *Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Jolynn Zu Lin OngCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Haoqing ShenCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Dennis KappeiCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-3582-2253
Leilei ChenCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-1987-3878
Allen Eng Juh YeohCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6454-976X
Shi Hao TanCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-7483-3668
Takaomi SandaCancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. takaomi_sanda@u.nus.edu.ORCID 0000-0003-1621-4954

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 18K19960Ministry of Education - Singapore (MOE) MOE-000061-00Ministry of Health -Singapore (MOH) MOH-000208-00Ministry of Health -Singapore (MOH) MOH-001225-00
6 · The paper itself

Abstract

The transcription factor MYB is frequently upregulated in T-cell acute lymphoblastic leukemia (T-ALL), a hematological malignancy originating from T-cell precursors. Here, we demonstrate that MYB plays a crucial role by regulating genes essential for T-ALL pathogenesis. Integrative analysis reveals a long MYB isoform, ENST00000367814.8, which is dominantly expressed and confers a proliferative advantage in T-ALL cells. Rapid depletion of MYB via dTAG-mediated protein degradation affects a large number of genes, which can be classified into early response or late response genes based on their kinetics. Early response genes include many genes involved in hematopoiesis, such as TAL1, RUNX1, GATA3, IKZF2, and CXCR4. Their expression can be recovered at later time-points, suggesting the presence of a negative feedback loop mechanism. In contrast, late response genes, which are continuously downregulated after MYB depletion, includes many genes involved in cell proliferation as well as TAL1 targets, thereby affecting the cellular phenotype.

Indexed as

Gene Expression Regulation, LeukemicPrecursor T-Cell Lymphoblastic Leukemia-LymphomaProto-Oncogene Proteins c-mybCell ProliferationHumansTranscription, GeneticMYB protein, humanProto-Oncogene Proteins c-myb

Identifiers

PMID39488662

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.