Evidence map›Paper›PMID 39488505›Full record

ArticleNature communications2024

Longitudinal genomics reveals carbapenem-resistant Acinetobacter baumannii population changes with emergence of highly resistant ST164 clone.

Haiyang Liu, Robert A Moran, Emma L Doughty, Xiaoting Hua, Ann E Snaith, Linghong Zhang, Xiangping Chen, Feng Guo, Willem van Schaik, Alan McNally and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Convergent evolution of ST2 and ST164 mediates dissemination of the blaAnnals of clinical microbiology and antimicrobials · 2026
    Article
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Six Years ofAntibiotics (Basel, Switzerland) · 2026
    Article
  9. Review
  10. Article
  11. Genomic characterization of carbapenem-resistantFrontiers in cellular and infection microbiology · 2026
    Article
  12. Article
  13. Article
  14. Comparative genomic insights into carbapenem-resistant versus susceptibleFrontiers in cellular and infection microbiology · 2026
    Article
  15. Prognostic Indicators of Carbapenem-ResistantHealth science reports · 2025
    Review
  16. Whole-genome sequencing ofMicrobial genomics · 2025
    Article
  17. Comparative analysis ofFrontiers in microbiology · 2025
    Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haiyang Liu *Centre of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, 158 Shangtang Road, 310014, Hangzhou, Zhejiang, China.
Robert A Moran *Institute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Emma L DoughtyInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Xiaoting HuaDepartment of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China.ORCID 0000-0001-8215-916X
Ann E SnaithInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Linghong ZhangDepartment of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China.
Xiangping ChenIntensive Care Unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China.
Feng GuoIntensive Care Unit, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 310016, Hangzhou, Zhejiang, China.
Willem van SchaikInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0001-5832-0988
Alan McNallyInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. a.mcnally.1@bham.ac.uk.ORCID 0000-0002-3099-630X
Yunsong YuCentre of Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, 158 Shangtang Road, 310014, Hangzhou, Zhejiang, China. yvys119@zju.edu.cn.ORCID 0000-0003-2903-918X

Funding

National Natural Science Foundation of China (National Science Foundation of China) U22A20338, 32270183, 81861138054RCUK | Medical Research Council (MRC) MR/S013660/1
6 · The paper itself

Abstract

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a persistent nosocomial pathogen that poses a significant threat to global public health, particularly in intensive care units (ICUs). Here we report a three-month longitudinal genomic surveillance study conducted in a Hangzhou ICU in 2021. This followed a three-month study conducted in the same ICU in 2019, and infection prevention and control (IPC) interventions targeting patients, staff and the ICU environment. Most A. baumannii isolated in this ICU in 2021 were CRAB (80.9%; 419/518) with higher-level resistance to carbapenems. This was accompanied by the proportion of global clone 2 (GC2) isolates falling from 99.5% in 2019 to 50.8% (213/419) in 2021. The phylogenetic diversity of GC2 increased, apparently driven by regular introductions of distinct clusters in association with patients. The remaining CRAB (40.2%; 206/419) were a highly clonal population of ST164. Isolates of ST164 carried bla

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial Agentsbeta-LactamasesCarbapenemsGenomicsIntensive Care UnitsMicrobial Sensitivity TestsPhylogenyAdultAgedBacterial ProteinsChinaCross InfectionDrug Resistance, Multiple, BacterialFemaleAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase NDM-1beta-LactamasescarbapenemaseCarbapenems

Identifiers

PMID39488505
PMCPMC11531505

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.