Evidence map›Paper›PMID 39488252›Full record

ReviewAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2025

Evaluation for genetic disease in kidney transplant candidates: A practice resource.

Elizabeth G Ames, Prince M Anand, Mir Reza Bekheirnia, Mona D Doshi, Mireille El Ters, Margaret E Freese, Rasheed A Gbadegesin, Lisa M Guay-Woodford, Anuja Java, Daniel Ranch and 3 more

Abstract readReview
In one paragraph

Review in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Beyond the acceptance decision: integrating genetic findings into lifelong living donor care.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Elizabeth G AmesDivision of Pediatric Genetics, Metabolism, and Genomic Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA.
Prince M AnandDepartment of Internal Medicine, Medical University of South Carolina, Lancaster, South Carolina, USA.
Mir Reza BekheirniaDepartments of Molecular and Human Genetics and Pediatrics, Baylor College of Medicine, Houston, Texas, USA; Michael E. Debakey VA Medical Center, Houston, Texas, USA.
Mona D DoshiDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Mireille El TersDivision of Nephrology, Department of Medicine, William von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA.
Margaret E FreeseDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Rasheed A GbadegesinDivision of Nephrology, Department of Pediatrics, Duke University School of Medicine, Durham, North Carolina, USA.
Lisa M Guay-WoodfordDivisions of Nephrology and Genetics, Research Institute and Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Anuja JavaDivision of Nephrology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Daniel RanchDepartment of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA.
Nancy M RodigDivision of Nephrology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
Xiangling WangCenter for Personalized Genetic Healthcare, Department of Kidney Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.
Christie P ThomasDivision of Nephrology, Department of Medicine, William von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, Minnesota, USA; Department of Internal Medicine, VA Medical Center, Iowa City, Iowa, USA. Electronic address: christie-thomas@uiowa.edu.

Funding

REGULATORS OF CALCINEURIN PATHWAYS AS DIAGNOSTIC AND THERAPEUTIC TARGETS FOR NEPHROTIC SYNDROMER01DK134347 · NIDDK · DUKE UNIVERSITY · PI Rasheed Adebayo Gbadegesin · 2023 to 2026
$2.6M
NIDDK NIH HHS R01 DK134347
6 · The paper itself

Abstract

The increasing availability of clinically approved genetic tests for kidney disease has spurred the growth in the use of these tests in kidney transplant practice. Neither the testing options nor the patient population where this should be deployed has been defined, and its value in kidney transplant evaluation has not been demonstrated. Transplant providers may not always be aware of the limitations of genetic testing and may need guidance on comprehending test results and providing counsel, as many centers do not have easy access to a renal genetic counselor or a clinical geneticist. In this practice resource, a working group of nephrologists, geneticists, and a genetic counselor provide a pragmatic, tailored approach to genetic testing, advocating for its use only where the genetic diagnosis or its exclusion can impact the choices available for transplantation or posttransplant management or the workup of living donor candidates at increased risk for heritable disease.

Indexed as

Genetic Diseases, InbornGenetic TestingKidney TransplantationGenetic CounselingHumansgenetic counselinggenetic testingMendelian inheritancerecurrent diseaserisk alleles

Identifiers

PMID39488252
PMCPMC13266825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.