Evidence map›Paper›PMID 39488010›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2024

Structural and functional correlates of olfactory reward processing in behavioral variant frontotemporal dementia.

Andrzej Sokołowski, Jesse A Brown, Ashlin R K Roy, Noah Cryns, Aaron Scheffler, Emily G Hardy, Samir Datta, William W Seeley, Virginia E Sturm, Bruce L Miller and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrzej SokołowskiDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Jesse A BrownDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Ashlin R K RoyDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Noah CrynsDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Aaron SchefflerDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Emily G HardyDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Samir DattaDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
William W SeeleyDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA; Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
Virginia E SturmDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Bruce L MillerDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
Howard J RosenDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.
David C PerryDepartment of Neurology, Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. Electronic address: David.Perry@ucsf.edu.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
Diagnostic and prognostic certainty in behavioral variant frontotemporal dementiaR01AG062758 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERRY, DAVID C · 2020 to 2025
$4.0M
Reward processing in genetic frontotemporal dementia and mood disordersR01AG059794 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERRY, DAVID C · 2019 to 2023
$4.0M
NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG052496NIA NIH HHS R01 AG059794NIA NIH HHS R01 AG062758
6 · The paper itself

Abstract

The behavioral variant of frontotemporal dementia (bvFTD) includes symptoms that reflect altered pursuit of rewards, including food, alcohol, and money. Little is known, however, about how these reward changes relate to atrophy and functional connectivity within reward-related regions. The goal of this study was to examine the structural and functional correlates of valence perception for olfactory rewards in 24 patients with bvFTD. Regression analysis of resting-state brain functional connectivity indicated that more positive valence ratings of olfactory stimuli were predicted by ventral pallidum connectivity to other reward circuit regions, particularly functional connectivity between ventral pallidum and bilateral anterior cingulate cortex/ventromedial prefrontal cortex. Structural analysis showed that atrophy of the anterior cingulate cortex was also significantly associated with perceiving stimuli as more rewarding. Finally, there was a significant interaction between ventral pallidum connectivity and atrophy of the anterior cingulate cortex. More specifically, the ventral pallidum connectivity had a greater effect on the positive perception of olfactory stimuli in the setting of low anterior cingulate cortex volume. These findings indicate that atrophy and functional connectivity within reward-relevant regions exert independent and interacting effects on the perception of pleasantness in bvFTD, potentially due to changes in hedonic "liking" signals.

Indexed as

Frontotemporal DementiaMagnetic Resonance ImagingRewardAgedAtrophyBasal ForebrainBrainBrain MappingFemaleGyrus CinguliHumansMaleMiddle AgedOlfactory PerceptionPrefrontal CortexbvFTDDementiaFunctional connectivityReward

Identifiers

PMID39488010
PMCPMC11809299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.