ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Bergamot Essential Oil Beverage: Preparation, Formulation Optimization, and Preliminary Evaluation of Antidepressant-like Effects in Mice Induced by Chronic Corticosterone Treatment.Foods (Basel, Switzerland) · 2026Article
- Nasal respiration modulates pain perception via the olfactory Bulb-Anterior cingulate cortex circuit.iScience · 2025Article
- Effects of Essential Oil Inhalation on the Enhancement of Plasma and Liver Lipid Metabolism in Mice.International journal of molecular sciences · 2025Article
- [Enriched environment reduces pyramidal neuron excitability in the anterior cingulate cortex to alleviate restraint stress-induced anxiety-like behaviors in mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Anxiolytic Effects of Natural Products: Pathological Mechanisms, Molecular Targets, Therapeutic Prospects.Neuropsychiatric disease and treatment · 2025Review
- Endocannabinoids Block Headache and Anxiety Comorbidity via Two-Pronged Anterior Insular Projections.Research (Washington, D.C.) · 2025Article
- A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
12 authors.
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Abstract
Aromatic essential oils have been shown to relieve anxiety and enhance relaxation, although the neural circuits underlying these effects have remained unknown. Here, it is found that treatment with 1.0% bergamot essential oil (BEO) exerts anxiolytic-like effects through a neural circuit projecting from the anterior olfactory nucleus (AON) to the anterior cingulate cortex (ACC) in acute restraint stress model mice. Collectively, in vivo two-photon calcium imaging, viral tracing, and whole-cell patch clamp recordings show that inhalation exposure to 1.0% BEO can activate glutamatergic projections from the AON to GABAergic neurons in the ACC, which drives inhibition of local glutamatergic neurons (AON
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Registered trials
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