Evidence map›Paper›PMID 39487854›Full record

ArticleCancer immunology, immunotherapy : CII2024

Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells.

Katarzyna Stasiak, Aaron D Stevens, Ashley C Bolte, Colleen T Curley, Mirna Perusina Lanfranca, Robin S Lindsay, Ukpong B Eyo, John R Lukens, Richard J Price, Timothy N J Bullock and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katarzyna StasiakCarter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Aaron D StevensDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
Ashley C BolteDepartment of Neuroscience, University of Virginia, Charlottesville, USA.
Colleen T CurleyDepartment of Biomedical Engineering, University of Virgnia, Charlottesville, VA, USA.
Mirna Perusina LanfrancaCarter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.ORCID http://orcid.org/0000-0002-3845-2585
Robin S LindsayCarter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA.
Ukpong B EyoDepartment of Neuroscience, University of Virginia, Charlottesville, USA.
John R LukensDepartment of Neuroscience, University of Virginia, Charlottesville, USA.
Richard J PriceDepartment of Biomedical Engineering, University of Virgnia, Charlottesville, VA, USA.
Timothy N J BullockDepartment of Pathology, University of Virginia, Charlottesville, VA, USA.
Victor H EngelhardCarter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA. vhe@virginia.edu.

Funding

Women's Oncology Program - WONP30CA044579 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Thomas P. Loughran · 1987 to 2026
$72.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
Supplement - Manipulating microenvironment and vasculature to enhance T cell infiltration into tumorsR01CA233716 · NCI · UNIVERSITY OF VIRGINIA · PI ENGELHARD, VICTOR H, KELLY, KIMBERLY A. · 2019 to 2023
$2.9M
Immunotherapeutic Nanoparticle Delivery to Melanoma With MR-Guided Focused UltrasoundR01CA197111 · NCI · UNIVERSITY OF VIRGINIA · PI BULLOCK, TIMOTHY N, ENGELHARD, VICTOR H · 2015 to 2019
$2.6M
Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomasR01EB030409 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2021 to 2024
$2.3M
Leveraging MR-Guided Focused Ultrasound to Potentiate Immunotherapy for GBMR21CA226607 · NCI · UNIVERSITY OF VIRGINIA · PI BULLOCK, TIMOTHY N · 2019 to 2020
$383k
Lymph node-like vasculature and naive T cell infiltration into tumorsR21CA181794 · NCI · UNIVERSITY OF VIRGINIA · PI ENGELHARD, VICTOR H · 2015 to 2016
$378k
Meningeal lymphatic dysfunction in traumatic brain injury: roles in disease pathogenesis andlong-term outcomes.F30AG069396 · NIA · UNIVERSITY OF VIRGINIA · PI BOLTE, ASHLEY C · 2020 to 2022
$147k
Melanoma Research Alliance 348727NCI NIH HHS P30 CA044579NCI NIH HHS R01 CA197111NCI NIH HHS R01 CA233716NCI NIH HHS R21 CA181794NCI NIH HHS R21 CA226607NIAID NIH HHS T32 AI007496NIA NIH HHS F30 AG069396NIBIB NIH HHS R01 EB030409University of Virginia Parsons-Weber-Parsons Fellowship in Oncology ResearchUniversity of Virginia Wagner FellowshipU.S. Public Health Service R01 CA181794
6 · The paper itself

Abstract

Patients with metastatic brain melanomas (MBM) experience shorter-lasting survival than patients with extracranial metastases, and this is associated with a higher fraction of dysfunctional CD8 T cells. The goal of this study was to understand the underlying cause of T cell dysfunction in MBM. To accomplish this, we compared murine B16 melanomas implanted intracranially (IC) or subcutaneously (SC). CD8 T cell activation was not altered, but representation in IC tumors was lower. Transferred activated or naïve CD8 T cells accumulated in similar numbers in both tumors, suggesting that the vasculature does not differentially impair T cell presence. Surprisingly, we found no evidence for T cell activation in draining lymph nodes of SC or IC tumor-bearing mice, consistent with the fact that dendritic cells (DC) that had acquired tumor antigen showed an immature phenotype. Instead, T cell activation occurred within both tumors, where the majority of tumor antigen

Indexed as

Brain NeoplasmsCD8-Positive T-LymphocytesDendritic CellsMelanomaMelanoma, ExperimentalMice, Inbred C57BLMyeloid CellsAnimalsFemaleLymphocyte ActivationMiceSkin NeoplasmsAntigen presenting cellsBrainMelanomaMetastasisT cells

Identifiers

PMID39487854
PMCPMC11531463

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.