Evidence map›Paper›PMID 39487759›Full record

ArticleCell transplantation

Human Stem Cell-Derived Cardiomyocytes Integrate Into the Heart of Monkeys With Right Ventricular Pressure Overload.

Jodi Scholz, Frank J Secreto, Joan Wobig, Joe Kurian, Clint Hagen, Alexandra Zinnen, Don Vu, Steven J Johnson, Frank Cetta, Yasir Qureshi and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Biologics for cardiovascular diseases: from bench to bedside.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jodi ScholzDepartment of Comparative Medicine, Mayo Clinic, Rochester, MN, USA.
Frank J SecretoDepartment of Medicine, Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Joan WobigTodd and Karen Wanek Family Program for HLHS at Mayo Clinic, Rochester, MN, USA.
Joe KurianWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Clint HagenTodd and Karen Wanek Family Program for HLHS at Mayo Clinic, Rochester, MN, USA.
Alexandra ZinnenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Don VuWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Steven J JohnsonWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Frank CettaDivision of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Yasir QureshiDivision of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-9898-2318
Rachel ReamsStageBio, Mt. Jackson, VA, USA.
Bryan CannonDivision of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Christina M HeyerTodd and Karen Wanek Family Program for HLHS at Mayo Clinic, Rochester, MN, USA.
Minhwang ChangHeartWorks, Rochester, MN, USA.
Numrah FadraDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
Jennifer CoonenWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Andres MejiaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Jennifer M HayesWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Puja BasuWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Saverio CapuanoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Viktoriya BondarenkoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Jeanette M MetzgerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.
Timothy J NelsonDepartment of Medicine, Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Marina E EmborgWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-9351-6641

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
NIH HHS P51 OD011106
6 · The paper itself

Abstract

Cardiac ventricular pressure overload affects patients with congenital heart defects and can cause cardiac insufficiency. Grafts of stem cell-derived cardiomyocytes are proposed as a complementary treatment to surgical repair of the cardiac defect, aiming to support ventricular function. Here, we report successful engraftment of human induced pluripotent stem cell-derived cardiac lineage cells into the heart of immunosuppressed rhesus macaques with a novel surgical model of right ventricular pressure overload. The human troponin+ grafts were detected in low-dose (2 × 10

Indexed as

Induced Pluripotent Stem CellsMacaca mulattaMyocytes, CardiacAnimalsCell DifferentiationDisease Models, AnimalHumansMaleMyocardiumcardiomyocytesgraftsrhesusright ventricular pressure overloadstem cells

Identifiers

PMID39487759
PMCPMC11531674

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.