ArticleJournal of animal science2024
Evaluation of guanidinoacetic acid supplementation on finishing beef steer growth performance, skeletal muscle cellular response, and carcass characteristics.
Article in Journal of animal science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The Welfare Impact of Heat Stress in South American Beef Cattle and the Cost-Effectiveness of Shade Provision.Animals : an open access journal from MDPI · 2026Article
- Local insulin-like growth factor-1 and Akt/mTOR signaling in skeletal muscle of lubabegron-supplemented finishing steers.Journal of animal science · 2026Article
- Methionine and guanidinoacetic acid supplementation throughout the periconceptual period of gestation altered metabolite concentrations and fetal development in beef heifers.Journal of animal science · 2026Article
- Effects of rumen-protected guanidinoacetic acid on fat deposition, antioxidant capacity, fatty acid profiles in subcutaneous adipose of Tibetan sheep: integrated RNA-seq and LC-MS/MS analysis.Frontiers in veterinary science · 2026Article
- Integrated transcriptomic and phenotypic analysis reveals tissue-specific regulatory effects of guanidinoacetic acid in cattle.BMC genomics · 2025Article
- Guanidinoacetic Acid and Its Impact on the Performance, Carcass and Meat Quality of Growing and Finishing Nellore Cattle.Veterinary sciences · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study elucidated the effects of dosage-dependent guanidinoacetic acid (GAA) supplementation on growth performance, muscle responses, and carcass characteristics in finishing beef steers. Thirty crossbred Red Angus beef steers (395 ± 28.09 kg) were randomly assigned one of three treatments during a 146-d feedlot study: basal diet without GAA supplementation (CONTROL), 1g of GAA per 100 kg of body weight (BW) daily (LOWGAA), and 2 g of GAA per 100 kg of BW daily (HIGHGAA). Individual feed intake was monitored daily, growth performance parameters were collected every 28 d, and longissimus muscle (LM) biopsies occurred every 56 d. In biopsied LM, greater (P = 0.048) mRNA expression of IGF-1 was observed in LOWGAA steers on day 112 compared to the CONTROL group. LOWGAA steers also exhibited greater expression of myosin heavy chain (MHC) I compared to CONTROL steers (P < 0.05) and MHC IIA compared to both CONTROL and HIGHGAA treatment groups (P < 0.01) on day 112. GAA supplementation resulted in no change in carcass characteristics, serum and LM tissue metabolites, LM composition, and Warner-Bratzler shear force values (P > 0.05). Data collected from this study demonstrate the influence of GAA supplementation on the gene expression of MHC isoforms and their role in skeletal muscle growth, differentiation, and muscle fiber-typing.
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