ArticleActa paediatrica (Oslo, Norway : 1992)2025
Higher initial levothyroxine doses and very early treatment start may lead to better cognitive outcomes in children with congenital hypothyroidism.
Article in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A review on levothyroxine therapy and bone age in children with long-standing untreated acquired hypothyroidism.Bioinformation · 2026Article
- Congenital Hypothyroidism: Long-Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose.Clinical endocrinology · 2025Article
- Universal Decentralized Cord Blood TSH Screening Should Be Offered as Routine Delivery Care in Limited-Resource Settings.International journal of neonatal screening · 2025Article
- Higher initial levothyroxine doses and very early treatment start may lead to better cognitive outcomes in children with congenital hypothyroidism.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
aimThis study aimed to assess the cognitive development of individuals with congenital hypothyroidism.
methodsUsing hospital records, we identified 180 patients with congenital hypothyroidism born between 1980 and 2018 in Turku and Kuopio University Hospital catchment areas. Cognitive development was evaluated in 22 adults (7 males and 15 females) and 20 children (8 males and 12 females) using age-specific Wechsler Intelligence Scales. Full-scale IQ (FSIQ) and the four indices were compared to standardisation samples. Simple linear regression was used to test whether treatment-related variables predicted FSIQ.
resultsFSIQ and its four indices differed significantly from the standardisation sample in adults with congenital hypothyroidism (FSIQ 87.64, SD 13.70, p < 0.001) but not in children (FSIQ 97.90, SD 15.12). Adults had received a lower initial levothyroxine dose than children (8.1 mg/kg, 95% CI 7.2-9.0 vs. 10.2 mg/kg 9.7-10.7, p < 0.001), and their treatment was initiated later (4.8 days, 95% CI 4.0-5.6 vs. 3.6 days, 2.9-4.2, p = 0.018).
conclusionAdults with congenital hypothyroidism had a significantly lower FSIQ compared to the population standard, while children's FSIQ did not differ. Our findings suggest that a higher initial levothyroxine dose together with very early treatment start may lead to better cognitive outcomes.
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