Evidence map›Paper›PMID 39487345›Full record

ArticleNeuromolecular medicine2024

Anthropometric and Demographic Features Affect the Interpretation of Cerebrospinal Fluid Biomarkers in Patients with Different Dementia Syndromes and Cognitively Healthy Adults.

Fabricio Ferreira de Oliveira, Marjorie Câmara Miraldo, Eduardo Ferreira de Castro-Neto, Sandro Soares de Almeida, Sandro Luiz de Andrade Matas, Paulo Henrique Ferreira Bertolucci, Maria da Graça Naffah-Mazzacoratti

Abstract read
PubMed Publisher
In one paragraph

Article in Neuromolecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fabricio Ferreira de OliveiraDepartment of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua Botucatu 740, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil. fabricioferreiradeoliveira@hotmail.com.ORCID 0000-0002-8311-0859
Marjorie Câmara MiraldoDepartment of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua Botucatu 740, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil.ORCID 0000-0002-1035-027X
Eduardo Ferreira de Castro-NetoDepartment of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua Botucatu 740, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil.ORCID 0000-0002-2073-3004
Sandro Soares de AlmeidaDepartment of Biophysics, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.ORCID 0000-0002-4392-0953
Sandro Luiz de Andrade MatasDepartment of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua Botucatu 740, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil.ORCID 0000-0002-0479-2450
Paulo Henrique Ferreira BertolucciDepartment of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua Botucatu 740, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil.ORCID 0000-0001-7902-7502
Maria da Graça Naffah-MazzacorattiDepartment of Neurology and Neurosurgery, Escola Paulista de Medicina, Federal University of São Paulo (UNIFESP), Rua Botucatu 740, Vila Clementino, São Paulo, SP, CEP 04023-900, Brazil.ORCID 0000-0002-3468-360X

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/10109-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/18125-0
6 · The paper itself

Abstract

Clinical distinction between dementia with Lewy bodies (DLB) and late-onset Alzheimer's disease (AD) is difficult, while several features might affect the analyses of biomarkers. This study aimed to verify associations of anthropometric and demographic features with cerebrospinal fluid biomarkers, their ratios, and restructured traditional regression formulas in patients with DLB and AD, as well as in cognitively healthy controls. Consecutive outpatients with DLB were paired with outpatients with AD according to sex, dementia stage, and cognitive status, and with controls according to sex and age to investigate associations of sex, age, dementia duration, total sleep time, body mass index, alcohol use, smoking, sanitation, and APOE-ε4 alleles on the measurement of cerebrospinal fluid α-synuclein, biomarker ratios, and restructured traditional regression formulas involving amyloid-β (Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBiomarkersLewy Body Diseasetau ProteinsAgedAged, 80 and overalpha-SynucleinAnthropometryApolipoprotein E4Body Mass IndexDiagnosis, DifferentialFemaleHumansMaleMiddle Agedalpha-SynucleinAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)Apolipoprotein E4BiomarkersMAPT protein, humanPeptide FragmentsSNCA protein, humantau ProteinsAlzheimer diseaseApoEBiomarkersCerebrospinal fluidLewy body dementiaSex

Identifiers

PMID39487345

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.