ArticleScientific reports2024
Mechanical fatigue in microtubules.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Kinesin-Induced Buckling Reveals the Limits of Microtubule Self-Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Molecular resilience of neurons to repetitive mechanical compression.Communications biology · 2026Article
- The roles of the microtubule cytoskeletal network in cardiac mechanobiology.Journal of cell science · 2026Review
- Biomechanically optimized 3D-Printed titanium prostheses with stiffener arrangement for critical femoral diaphyseal defects: early weight-bearing capacity and combat readiness validated through integrated biomechanical-FEA approach.Frontiers in bioengineering and biotechnology · 2025Article
- Can repetitive mechanical motion cause structural damage to axons?Frontiers in molecular neuroscience · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Mechanical failure of biological nanostructures due to sustained force application has been studied in great detail. In contrast, fatigue failure arising from repeated application of subcritical stresses has received little attention despite its prominent role in engineering and potentially biology. Here, paclitaxel-stabilized microtubules are up to 256 times bent into sinusoidal shapes of varying wavelength and the frequency of breaking events are observed. These experiments allow the calculation of fatigue life parameters for microtubules. Repeated buckling due to 12.5% compression-equal to the compression level experienced by microtubules in contracting cardiomyocytes - results in failure after in average 5 million cycles, whereas at 20.0% compression failure occurs after in average one thousand cycles. The fatigue strength (Basquin) exponent B is estimated as - 0.054±0.009.
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Registered trials
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