Evidence map›Paper›PMID 39487263›Full record

ArticleAAPS PharmSciTech2024

Strap-on Buoyant Device to Enhance Gastrointestinal Tract Retention of Felodipine Osmotic Pump Tablets.

Qijia Ni, Zeru Li, Libumo Baqing, Tianfu Li, Huipeng Xu, Falan Li, Ningning Peng, Caifen Wang, Jianhua Lu, Zhigang Wang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in AAPS PharmSciTech, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Qijia Ni *Anhui University of Chinese Medicine, Hefei, 230000, China.
Zeru Li *Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Libumo Baqing *Anhui University of Chinese Medicine, Hefei, 230000, China.
Tianfu LiShenyang Pharmaceutical University, Shenyang, 110016, China.
Huipeng XuCenter for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
Falan LiAnhui University of Chinese Medicine, Hefei, 230000, China.
Ningning PengShenyang Pharmaceutical University, Shenyang, 110016, China.
Caifen WangCenter for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201210, China.
Jianhua LuNantong Haimen People's Hospital, Nantong, 226199, China.
Zhigang WangNantong Haimen People's Hospital, Nantong, 226199, China.
Kai WangInnoStar Bio-tech Nantong Co., Ltd, Nantong, 226133, China.
Chao JiangInnoStar Bio-tech Nantong Co., Ltd, Nantong, 226133, China.
Li WuAnhui University of Chinese Medicine, Hefei, 230000, China.
Ye YangAnhui University of Chinese Medicine, Hefei, 230000, China. Y.Yang@ahtcm.edu.cn.
Hua ZhouHefei Lifeon Pharmaceutical Co., Ltd, Hefei, 230088, China. zh@lifeon.cn.
Yongdong GuInnoStar Bio-tech Nantong Co., Ltd, Nantong, 226133, China. ydgu@innostar.cn.
Jiwen ZhangAnhui University of Chinese Medicine, Hefei, 230000, China. jwzhang@simm.ac.cn.ORCID http://orcid.org/0000-0002-6497-6606

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osmotic pump systems require prolonged retention time in the stomach to provide enhanced bioavailability and regulated release, which is quite challenging. This study used a three-dimensional printing (3DP) technique combined with a gastro-retentive floating device (GRFD) to extend the retention of the osmotic pump in the stomach and enhance its bioavailability. The strap-on buoyant device was fabricated by stereolithography 3DP and incorporated a felodipine osmotic pump tablet used in clinical practice, which enabled it to float in the stomach or dissolution media without any floating lag time. The components of the device were affixed using a snap-fix mechanism. GRFD dissolution study revealed a notable in vitro floating capability, lasting over 24 h, with a release profile similarity factor f

Indexed as

Biological AvailabilityFelodipineGastrointestinal TractOsmosisTabletsAnimalsDelayed-Action PreparationsDogsDrug Delivery SystemsDrug LiberationMalePrinting, Three-DimensionalSolubilityDelayed-Action PreparationsFelodipineTabletsGastro-retentive floating deviceOsmotic pumpPharmacokineticStereolithography three-dimensional printing

Identifiers

PMID39487263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.