ArticleNature communications2024
Classification of distinct tendinopathy subtypes for precision therapeutics.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
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- Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes.Bone research · 2026Article
- Optimised Deep Learning for Gastrointestinal Polyp Classification: A Controlled Benchmark of Five CNN and Transformer Architectures with Grad-CAM Interpretability.Diagnostics (Basel, Switzerland) · 2026Article
- Comparative Efficacy and Safety of Intra-Articular Adipose-Derived, Bone Marrow-Derived, and Peripheral Blood-Derived Stem Cell Injections for Knee Osteoarthritis: A Systematic Review.Bioengineering (Basel, Switzerland) · 2026Review
- Transcriptomic Analysis of Tendon Healing Using an Extracellular Matrix-Coated, Polyurethane Scaffold.Bioengineering (Basel, Switzerland) · 2026Article
- CBAM-Xception: An Attention-Guided Framework for Skin Cancer Classification.Journal of imaging informatics in medicine · 2026Article
- Proteome profiles of esophageal squamous cell carcinoma tie mitochondrial complex I to immunotherapy.EMBO molecular medicine · 2026Article
- SkinFormer: a hybrid vision transformer and ConvNeXtV2 approach for skin cancer detection and segmentation.Scientific reports · 2026Article
- 18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy.Journal of translational medicine · 2026Article
- Applications of artificial intelligence in mechanical engineering for the field of upper limb exoskeletons.Scientific reports · 2026Article
- Effect of Knee Joint Meniscus Tears on Joint Cartilage Contact and Pressure with Finite Element Analysis.Biomedicines · 2026Article
- Shockwave or Ultrasound Therapy for Tendinopathy? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Bone-CNN: A Lightweight Deep Learning Architecture for Multi-Class Classification of Primary Bone Tumours in Radiographs.Biomedicines · 2026Article
- Biomimetic "Tendon Band-Aid" regulates inflammatory microenvironment and tenogenic differentiation for tendinopathy regeneration.Journal of nanobiotechnology · 2026Article
- Kinematic determinants of take-off performance in elite and sub-elite male long jumpers: a competition-based two-dimensional motion analysis.Frontiers in physiology · 2026Article
- MBNL1-mediated alternative splicing in cancer: underlying mechanism, isoform regulation, and translational perspectives.Frontiers in molecular biosciences · 2026Review
- Deep-Fed: A comprehensive solution for precise bone fracture identification in athletes.PloS one · 2026Article
- A systematic characterization of amino acid metabolism-related genes reveals molecular subtypes and a prognostic signature in bladder cancer.Frontiers in oncology · 2026Article
- Lymphatic-stem cell crosstalk promotes tendon regeneration via Notch1-Srebp2-mediated cholesterol metabolism.Nature communications · 2025Article
- SLC8A1 as a novel susceptibility gene in facilitating tendinopathy: insights into its mechanisms from Mendelian randomization and experimental validation.Molecular cytogenetics · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
22 authors.
Funding
Abstract
Rotator cuff tendinopathy is the most common tendinopathy type with the worst prognosis. Conventional treatments often elicit heterogeneous drug responses due to the diversity of tendinopathy. Hence, this study attempted a classification of 126 diseased tendons into three distinct subtypes with opposite pathogenic mechanisms based on transcriptomic and clinical features. The hypoxic atrophic subtype with white appearance (Hw) exhibits downregulated neovascularization pathways. The inflammatory proliferative subtype with white appearance (Iw) shows a moderate upregulation of inflammatory characteristics. The inflammatory proliferative subtype with red appearance (Ir) exhibits the highest levels of upregulated neovascularization and inflammatory pathways, along with severe joint dysfunction. We then established research models, including subtype-specific simulations in animal models and clinical data analysis. These revealed that glucocorticoid, a controversial commonly used drug, was only effective in treating the Ir subtype. Hence, the tendinopathy subtypes elucidated in this study have significant implications for developing precision treatment of tendinopathy.
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