ArticleJournal of pediatric gastroenterology and nutrition2025
Long-term follow-up of children with Crohn's disease and small bowel mucosal lesions detected through video capsule endoscopy.
Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pediatric video capsule endoscopy: diagnostic yield, safety, and clinical impact in a tertiary center.Frontiers in pediatrics · 2026Article
- Feasibility and Safety of Small Bowel Capsule Endoscopy in Very Early-Onset Inflammatory Bowel Disease: A Multi-Institutional Study.Inflammatory bowel diseases · 2025Article
- Long-term follow-up of children with Crohn's disease and small bowel mucosal lesions detected through video capsule endoscopy.Journal of pediatric gastroenterology and nutrition · 2025Article
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4 authors.
Funding
Abstract
objectivesWe report disease outcomes of pediatric Crohn's disease (CD) affecting the proximal small bowel (SB) and detected through video capsule endoscopy (VCE).
methodsWe undertook a retrospective review of CD patients with VCE performed under age 18 between 2003 and 2017 and having received any biologics. We identified patients from our institutional registry.
resultsEligible patients (n = 118) had their first VCE performed after a median of 0.1 years after diagnostic endoscopies at a median age of 12.2 years. The proximal SB disease group (Paris classification L4b inclusive) comprised 70 patients with extensive SB lesions in 81% and deep ulcers in 79%. Patients with Paris L1-3 disease with no findings in VCE or disease restricted to the terminal ileum comprised the control group. At first VCE, levels of albumin (34 vs. 37 g/L) and hemoglobin (117 vs. 127 g/L) were lower in SB patients (p < 0.02). After the first VCE, 68% were introduced to biologics, while 10% already received them. Follow-up VCE was performed after a median of 2.4 years (SB group n = 42; controls n = 21). Proximal SB findings had disappeared in 40% of SB patients, and extensive lesions and deep ulcers had decreased to 26% and 29%, respectively (p = 0.001). In the control group, one had progressed to proximal disease. During the clinical follow-up of a median of 4.7 years, one patient with SB underwent surgery for a jejunal stricture.
conclusionsProximal SB disease detected through capsule endoscopy abated in most patients with biological medication.
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