Evidence map›Paper›PMID 39486817›Full record

SynthesisBMJ open2024

Impact of BMI on fertility in an otherwise healthy population: a systematic review and meta-analysis.

Florence Turner, Simon G Powell, Hannan Al-Lamee, Anjali Gadhvi, Ellen Palmer, Andrew Drakeley, Victoria S Sprung, Dharani Hapangama, Nicola Tempest

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07765368 (BMI Versus Body Fat Percentage - Which is the Better Predictor of Fertility Outcomes in IVF Cycles?), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07765368 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

BMI Versus Body Fat Percentage - Which is the Better Predictor of Fertility Outcomes in IVF Cycles?

Typeobservational_patient_registrySponsorIWK Health CentreRan2026 to 2027Enrolled200ConditionsInfertility (IVF Patients), BMI, Bioelectrical Impedance Analysis, IVF OutcomesArmsMeasurement of BIA (Body Fat and Visceral Fat Percentage)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Florence TurnerCentre for Women's Health research, Department of Women's and Children's Health, Institute of Life Course and medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Simon G PowellCentre for Women's Health research, Department of Women's and Children's Health, Institute of Life Course and medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Hannan Al-LameeCentre for Women's Health research, Department of Women's and Children's Health, Institute of Life Course and medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Anjali GadhviCentre for Women's Health research, Department of Women's and Children's Health, Institute of Life Course and medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Ellen PalmerLiverpool Women's NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Andrew DrakeleyLiverpool Women's NHS Foundation Trust, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Victoria S SprungResearch Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, L3 3AF, UK.ORCID 0000-0002-2666-4986
Dharani HapangamaCentre for Women's Health research, Department of Women's and Children's Health, Institute of Life Course and medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK.
Nicola TempestCentre for Women's Health research, Department of Women's and Children's Health, Institute of Life Course and medical Sciences, University of Liverpool, Member of Liverpool Health Partners, Liverpool, L8 7SS, UK ntempest@liverpool.ac.uk.ORCID 0000-0003-3633-1592

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn increased body mass index (BMI) can lead to subfertility; however, current literature fails to exclude the effect of other confounding medical conditions, raising questions regarding the direct link between increased BMI and fertility outcomes.

objectivesTo conduct a systematic review and meta-analysis to elucidate the effects of increased BMI on fertility outcomes in females with no other comorbidities. SEARCH STRATEGY: A comprehensive search was conducted using EMBASE, MEDLINE and the Cochrane library from January 2000 until July 2023. DATA COLLECTION AND ANALYSIS: Two authors independently conducted data extraction and assessed study quality. Odds ratio (OR) (dichotomous data), standardised mean difference (SMD) (continuous data) and 95% CIs were calculated. MAIN

resultsNine eligible studies were identified: one natural conception and eight assisted reproductive technology (ART). Aggregated data revealed women with BMI ≥25 were less likely to attain clinical pregnancy (OR 0.76, 95% CIs 0.62 to 0.93, p=0.007), with BMI ≥30 associated with a further decreased likelihood of clinical pregnancy (OR 0.61, 95% CIs 0.39 to 0.98, p=0.04). Women with raised BMI required longer duration of stimulation (SMD=0.08, 95% CIs 0.00 to 0.16, p=0.04) and obtained reduced oocytes (SMD=-0.11, 95% CIs -0.18 to -0.04, p=0.002).

conclusionsThese data demonstrate an adverse impact of being overweight/obese on ART outcomes in women with no other diagnosed medical comorbidities and highlight the distinct lack of data concerning the effects of isolated obesity on natural conception. Infertility represents an enormous burden for couples and society; it is essential to identify and tackle modifiable risk factors to improve chances of conception. PROSPERO REGISTRATION NUMBER: CRD42022293631.

Indexed as

Body Mass IndexFertilityFemaleHumansInfertility, FemaleObesityPregnancyPregnancy RateReproductive Techniques, AssistedBody Mass IndexReproductive medicineSubfertility

Identifiers

PMID39486817
PMCPMC11529583

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.