Evidence map›Paper›PMID 39486632›Full record

ReviewDevelopmental biology2025

Development of ectodermal and endodermal taste buds.

Linda A Barlow

Abstract readReview
In one paragraph

Review in Developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Developing and regenerating a sense of taste.Current topics in developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Linda A BarlowDepartment of Cell and Developmental Biology, Rocky Mountain Taste and Smell Center, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA. Electronic address: Linda.Barlow@cuanschutz.edu.

Funding

Mechanisms of Adult Taste Bud RegenerationR01DC012383 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2012 to 2021
$3.4M
Characterization of progenitor populations in adult taste epitheliumR01DC018489 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2020 to 2024
$2.5M
The role of Kit signaling in taste bud regenerationR01DC021865 · NIDCD · UNIVERSITY OF COLORADO DENVER · PI Linda A Barlow · 2024 to 2026
$1.8M
Use of lingual organoids to screen for the impact of targeted cancer therapies on taste bud renewalR21CA236480 · NCI · UNIVERSITY OF COLORADO DENVER · PI BARLOW, LINDA A · 2019 to 2020
$372k
NCI NIH HHS R21 CA236480NIDCD NIH HHS R01 DC012383NIDCD NIH HHS R01 DC018489NIDCD NIH HHS R01 DC021865
6 · The paper itself

Abstract

The sense of taste is mediated primarily by taste buds on the tongue. These multicellular sensory organs are induced, patterned and become innervated during embryogenesis such that a functional taste system is present at birth when animals begin to feed. While taste buds have been considered ectodermal appendages, this is only partly accurate as only fungiform taste buds in the anterior tongue arise from the ectoderm. Taste buds found in the posterior tongue actually derive from endoderm. Nonetheless, both anterior and posterior buds are functionally similar, despite their disparate embryonic origins. In this review, I compare the development of ectodermal vs endodermal taste buds, highlighting the many differences in the cellular and molecular genetic mechanisms governing their formation.

Indexed as

EctodermEndodermTaste BudsAnimalsGene Expression Regulation, DevelopmentalHumansTongue

Identifiers

PMID39486632
PMCPMC11703678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.