Evidence map›Paper›PMID 39486045›Full record

ArticleBiomacromolecules2024

Front-Tracking and Gelation in Sessile Droplet Suspensions: What Can They Tell Us about Human Blood?

Sheila Bhatt, Peter A Smethurst, Gil Garnier, Alexander F Routh

Abstract read
In one paragraph

Article in Biomacromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sheila BhattInstitute for Energy and Environmental Flows, University of Cambridge, Bullard Laboratories, Madingley Road, Cambridge, CB3 0EZ, United Kingdom.ORCID 0009-0007-6174-7852
Peter A SmethurstComponent Development Laboratory, NHS Blood and Transplant, Cambridge Donor Centre, Cambridge, CB2 0PT, United Kingdom.
Gil GarnierBioPRIA, Department of Chemical Engineering, Monash University, Clayton VIC 31688, Australia.ORCID 0000-0003-3512-0056
Alexander F RouthInstitute for Energy and Environmental Flows, University of Cambridge, Bullard Laboratories, Madingley Road, Cambridge, CB3 0EZ, United Kingdom.ORCID 0000-0002-3443-3053

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently developed imaging techniques have been used to examine the redistribution of human red blood cells and comparator particles dispersed in carrier fluids within evaporating droplets. We demonstrate that progressive gelation initiates along an annular front, isolating a central pool that briefly remains open to particulate advection before gelation completes across the droplet center. Transition to an elastic solid is evidenced by cracking initiating proximal to front locations. The arrested flow of cellular components, termed a "halted front", has been investigated using a time-lapse analysis "signature". The presence of a deformable biocellular component is seen to be essential for front-halting. We show a dependence of front-halt radius on cell volume-fraction, potentially offering a low-cost means of measuring hematocrit. A simple model yields an estimate of the gel zero-shear yield-stress. This approach to understanding the drying dynamics of blood droplets may lead to a new generation of point-of-care diagnostics.

Indexed as

ErythrocytesSuspensionsGelsHumansGelsSuspensions

Identifiers

PMID39486045
PMCPMC11632657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.