Evidence map›Paper›PMID 39486012›Full record

ArticleThe Pediatric infectious disease journal2025

Infectious Morbidity and All-cause Mortality of Infants HIV-exposed Uninfected Compared to Infants HIV-unexposed Uninfected in Botswana.

Melanie M Dubois, Jennifer Jao, Shan Sun, Justine Legbedze, Sara Schenkel, Nicholas Mmasa, Samuel W Kgole, Gosego Masasa, Anna-Ursula Happel, Saori C Iwase and 7 more

Abstract read
In one paragraph

Article in The Pediatric infectious disease journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Effect of maternal HIV status on the early neonatal microbiome.Journal of the Pediatric Infectious Diseases Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Melanie M DuboisFrom the Division of Pediatric Infectious Diseases, Weill Cornell Medicine, New York City, New York.ORCID 0000-0001-9972-8533
Jennifer JaoDepartments of Pediatrics and Medicine, Northwestern University Feinberg School of Medicine.
Shan SunDepartments of Pediatrics and Medicine, Northwestern University Feinberg School of Medicine.
Justine LegbedzeDepartments of Pediatrics and Medicine, Northwestern University Feinberg School of Medicine.
Sara SchenkelDepartment of Pediatric Global Health, Massachusetts General Brigham, Boston, Massachusetts.
Nicholas MmasaCounty Durham and Darlington NHS Foundation Trust, Darlington Memorial Hospital, Darlington, United Kingdom.
Samuel W KgoleBotswana Harvard Health Partnership, Gaborone, Botswana.
Gosego MasasaBotswana Harvard Health Partnership, Gaborone, Botswana.
Anna-Ursula HappelDivision of Immunology, Department of Pathology.
Saori C IwaseDivision of Immunology, Department of Pathology.
Roxanna HaghighatHarvard Medical School.
Sikhulile MoyoBotswana Harvard Health Partnership, Gaborone, Botswana.
Tanvi S SharmaDivision of Infectious Diseases, Boston Children's Hospital.
Paul T EdlefsenFred Hutchinson Cancer Center.
Danica ShaoFred Hutchinson Cancer Center.
Heather JaspanDivision of Immunology, Department of Pathology.
Kathleen M PowisBotswana Harvard Health Partnership, Gaborone, Botswana.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Immune correlates of tuberculosis and non-tuberculosis infectious morbidity in Southern African HIV-exposed, uninfected infants.R01AI142670 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI POWIS, KATHLEEN · 2019 to 2023
$4.0M
The Tshilo Dikotla Study: Metabolic Outcomes of Children HIV/ARV-Exposed Uninfected in BotswanaR01DK109881 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI JAO, JENNIFER · 2016 to 2020
$3.0M
NIAID NIH HHS P30 AI060354NIAID NIH HHS R01 AI142670NIAID NIH HHS T32 AI007433NIDDK NIH HHS R01 DK109881
6 · The paper itself

Abstract

Some studies have reported increased infectious morbidity and all-cause mortality risk among infants HIV-exposed uninfected compared with infants HIV-unexposed uninfected. In a retrospective analysis of infants enrolled in the Botswana-based Tshilo Dikotla study, we found no difference in the prevalence of infectious hospitalizations or deaths from any cause in the first year of life by perinatal HIV exposure.

Indexed as

HIV InfectionsInfectious Disease Transmission, VerticalBotswanaFemaleHospitalizationHumansInfantInfant, NewbornMaleMorbidityPregnancyPrevalenceRetrospective Studies

Identifiers

PMID39486012
PMCPMC11828675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.