Evidence map›Paper›PMID 39485950›Full record

ArticleEpigenetics2024

Clinical significance of peripheral blood DDR1 and CtBP gene methylation detection in patients with acute pancreatitis.

Zeng-Hui Ma, Xue-Ni Ma, Hong-Wen Zhu, Long Cheng, Ling-Zhu Gou, De-Kui Zhang

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In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zeng-Hui MaThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Xue-Ni MaThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Hong-Wen ZhuThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Long ChengThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Ling-Zhu GouThe Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
De-Kui ZhangDepartment of Gastroenterology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the clinical value of methylation levels of peripheral blood DDR1 and CtBP genes in evaluating the severity of acute pancreatitis (AP). Collect 90 blood samples from AP patients and healthy volunteers, and test methylation levels of SPINK1, STAT3, KIT, CFTR, DDR1, CtBP1, CtBP2 genes by bisulfite amplicon sequencing (BSAS). The gene methylation and clinical predictors of SAP early prediction were determined by univariate and multifactorial analysis, respectively. (1) The methylation level of CtBP1 gene and MCTSI score were independent predictors of SAP, with AUC values of 0.723 and 0.8895, respectively. (2) The methylation levels of DDR1, CtBP2, CFTR and SPINK1 genes were statistically significant in HC group vs AP group, HC group vs MAP group, and HC group vs SAP group. (3) The combined detection of CtBP1 gene methylation level and MCTSI score predicted the sensitivity, specificity, AUC, and 95%CI of SAP were 0.750, 0.957, 0.902, and 0.816-0.989, respectively. (1) The methylation level of CtBP1 gene in peripheral blood is an independent risk factor for predicting SAP and is a potentially good predictor of SAP, and the combined testing with the MCTSI score does not further significantly improve the early predictive value for SAP. (2) The methylation levels of DDR1, SPINK1, CtBP2, and CFTR genes were potential indicators for recognizing AP.

Indexed as

Alcohol OxidoreductasesDiscoidin Domain Receptor 1DNA-Binding ProteinsDNA MethylationPancreatitisAcute DiseaseAdultAgedCarrier ProteinsCase-Control StudiesClinical RelevanceCo-Repressor ProteinsCystic Fibrosis Transmembrane Conductance RegulatorFemaleHumansMaleAlcohol OxidoreductasesCarrier ProteinsCFTR protein, humanCo-Repressor ProteinsCTBP2 protein, humanC-terminal binding proteinCystic Fibrosis Transmembrane Conductance RegulatorDDR1 protein, humanDiscoidin Domain Receptor 1DNA-Binding ProteinsSPINK1 protein, humanTrypsin Inhibitor, Kazal PancreaticAcute pancreatitisgene methylationpredictorsseverity

Identifiers

PMID39485950
PMCPMC11540100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.