ArticlePloS one2024
Regression analysis of topological indices for predicting efficacy of Alzheimer's drugs.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Degree-Based Topological Indices and Machine Learning for QSPR Modeling of Arthritis Drugs.ACS omega · 2026Article
- Developing a QSPR model for Alzheimer's drugs using topological indices and M-polynomial: A computational study.Scientific reports · 2025Article
- The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review).Molecular medicine reports · 2025Review
- Article
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3 authors.
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Abstract
Alzheimer's Disease(AD) is the most common type of dementia. It is a progressive disease beginning with mild memory loss and possibly leading to loss of the ability to carry on a conversation and respond to the environment. This study investigates the relationship between the chemical structure of potential AD drugs and their therapeutic efficacy using Multi-Criteria Decision-Making (MCDM) techniques including The approach for Order Preference by Similarity to Ideal Solution (TOPSIS) and Simple Additive Weighting (SAW) method. A comprehensive dataset comprising molecular descriptors and corresponding pharmacological properties, i.e., melting point, boiling point, molecular weight and density of AD drugs was compiled from diverse sources. Topological indices were calculated to capture the structural characteristics of these compounds. Application of TOPSIS and SAW through Entropy method helps obtain optimal drugs for curing AD. Quantitative Structure Property Relationships (QSPR) analysis has been done between properties and topological indices of AD's drug structures. Results revealed significant relations between specific topological indices and drug efficacy, providing insights into the structural features crucial for AD treatment efficacy. This approach offers a promising avenue for rational drug design and optimization in the quest for novel AD therapeutics.
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