Evidence map›Paper›PMID 39485742›Full record

ArticlePloS one2024

Cerebellar repetitive transcranial magnetic stimulation has no effect on contraction-induced facilitation of corticospinal excitability.

Akiyoshi Matsugi, Aki Tsuzaki, Soichi Jinai, Yohei Okada, Nobuhiko Mori, Koichi Hosomi

Abstract read
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akiyoshi MatsugiFaculty of Rehabilitation, Shijonawate Gakuen University, Daitou City, Osaka, Japan.ORCID 0000-0002-3244-0874
Aki TsuzakiFaculty of Rehabilitation, Shijonawate Gakuen University, Daitou City, Osaka, Japan.
Soichi JinaiFaculty of Rehabilitation, Shijonawate Gakuen University, Daitou City, Osaka, Japan.
Yohei OkadaNeurorehabilitation Research Center of Kio University, Koryo-cho, Kitakatsuragi-gun, Nara, Japan.
Nobuhiko MoriDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.ORCID 0000-0001-6537-6322
Koichi HosomiDepartment of Neurosurgery, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan.ORCID 0000-0001-7731-3302

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate whether the cerebellum contributes to contraction-induced facilitation (CIF) of contralateral corticospinal excitability. To this end, repetitive cerebellar transcranial magnetic stimulation (TMS) was used to test whether it modulates CIF. Overall, 20 healthy young individuals participated in the study. Single-pulse TMS was applied to the left primary motor cortex to induce motor-evoked potentials (MEP) on electromyography of the right first dorsal interosseous (FDI) muscle to test corticospinal excitability. This measurement was conducted during contraction (10% maximum voluntary contraction [MVC]) and rest (0% MVC) of the FDI muscle. CIF, cerebellar brain inhibition (CBI), cortical silent period (cSP), and resting motor threshold (rMT) were measured before and after low-frequency repetitive TMS (crTMS) of the right cerebellum to downregulate cerebellar output. The CIF (contraction/rest of the MEP), CBI (conditioned/unconditioned MEP) during contraction, cSP, and rMT were not affected by crTMS. At rest, CBI was decreased. These findings indicated that the primary motor cortex function for the increase in corticospinal excitability was not affected by crTMS. This study contributes to our understanding of the role of the cerebellum in motor control. Additionally, it may inform decision-making for the site of cerebellar ataxia treatment using non-invasive brain stimulation.

Indexed as

CerebellumElectromyographyEvoked Potentials, MotorMotor CortexMuscle ContractionTranscranial Magnetic StimulationAdultFemaleHumansMaleMuscle, SkeletalPyramidal TractsYoung Adult

Identifiers

PMID39485742
PMCPMC11530076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.