Evidence map›Paper›PMID 39485736›Full record

ArticleJournal of medicinal chemistry2024

Synthesis and Biological Evaluation of New Chalcogen Semicarbazone (

Mercedes Rubio-Hernández, Verónica Alcolea, Elany Barbosa da Silva, Miriam A Giardini, Thaís H M Fernandes, Nuria Martínez-Sáez, Anthony J O'Donoghue, Jair L Siqueira-Neto, Silvia Pérez-Silanes

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. NewRSC medicinal chemistry · 2025
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mercedes Rubio-HernándezISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-7375-4335
Verónica AlcoleaISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain.
Elany Barbosa da SilvaSkaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-1926-3500
Miriam A GiardiniSkaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0002-6510-2409
Thaís H M FernandesSkaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.ORCID 0000-0001-5910-0792
Nuria Martínez-SáezDepartment of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-0799-5106
Anthony J O'DonoghueSkaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Jair L Siqueira-NetoSkaggs School of Pharmacy and Pharmaceutical Sciences and Center for Discovery and Innovation in Parasitic Diseases, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.
Silvia Pérez-SilanesISTUN Institute of Tropical Health, Department of Pharmaceutical Sciences, Universidad de Navarra, 31008 Pamplona, Spain.ORCID 0000-0002-6284-4546

Funding

Targeting the Genus Leishmania with Small MoleculesR01AI151639 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BROWN, LAUREN ELAINE, SCHAUS, SCOTT EDWARD · 2021 to 2025
$3.8M
bill and melinda gates INV-039628NIAID NIH HHS R01 AI151639
6 · The paper itself

Abstract

Chagas disease is caused by the eukaryote parasite

Indexed as

AzolesChagas DiseaseSemicarbazonesTrypanocidal AgentsTrypanosoma cruziAnimalsCathepsin LCell LineChalcogensHumansMiceOrganoselenium CompoundsProtozoan ProteinsStructure-Activity RelationshipAzolesCathepsin LChalcogensOrganoselenium CompoundsProtozoan ProteinsSemicarbazonesTrypanocidal Agents

Identifiers

PMID39485736
PMCPMC12320831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.