Evidence map›Paper›PMID 39485592›Full record

ReviewPituitary2024

Approach to the patient with controlled acromegaly and acromegalic arthropathy: clinical diagnosis and management.

Iris C M Pelsma, Herman M Kroon, Cornelie D Andela, Enrike M J van der Linden, Margreet Kloppenburg, Nienke R Biermasz, Kim M J A Claessen

Abstract readCase ReportsReview
In one paragraph

Review in Pituitary, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026
    Review
  3. Review
  4. Article
  5. Pegvisomant in managing comorbidities of acromegaly: a review.Reviews in endocrine & metabolic disorders · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iris C M PelsmaDepartment of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. I.C.M.Pelsma@lumc.nl.ORCID http://orcid.org/0000-0003-4956-4037
Herman M KroonDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-5879-2990
Cornelie D AndelaDepartment of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3410-8701
Enrike M J van der LindenDepartment of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0009-0004-5939-6609
Margreet KloppenburgDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-9294-2307
Nienke R BiermaszDepartment of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-5817-3594
Kim M J A ClaessenDepartment of Medicine, Division of Endocrinology, and Center for Endocrine Tumors Leiden, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-8250-7224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Following the description of an illustrative case of a 70-year-old female patient with longstanding active acromegaly and invalidating, progressive joint complaints, current insights regarding diagnosis, treatment, and long-term management of acromegalic arthropathy are summarized. Since clinical trials on this topic are lacking, the reported recommendations are based on extensive clinical and research experience with this clinical entity, and on established diagnostics and interventions in patients with other rheumatic diseases. The cornerstones of the management of acromegalic arthropathy remains normalization of growth hormone and insulin growth factor-1 levels. However, patients with severe or progressive acromegalic arthropathy require a multidisciplinary approach to determine adequate diagnostics and treatment options. Because of the high prevalence and invalidating character of acromegalic arthropathy, developing evidence-based effective prevention and treatment strategies, preferably by international collaboration within rare disease networks, e.g., Endo-ERN, is a clear unmet need.

Indexed as

AcromegalyJoint DiseasesAgedFemaleHuman Growth HormoneHumansInsulin-Like Growth Factor IHuman Growth HormoneInsulin-Like Growth Factor IAcromegalyArthropathyManagementOsteoarthritisTreatment

Identifiers

PMID39485592
PMCPMC11632006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.