Menthol as an effective inhibitor of quorum sensing and biofilm formation in Candida albicans and Candida glabrata by targeting the transcriptional repressor TUP1.

Pouria Khodavandi, Maryam Miri Soogh, Fahimeh Alizadeh, Alireza Khodavandi, Sadegh Nouripour-Sisakht

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Pouria KhodavandiDepartment of Animal Science, Shiraz University, Shiraz, Iran.

Maryam Miri SooghDepartment of Microbiology, Yasuj Branch, Islamic Azad University, Yasuj, Iran.

Fahimeh AlizadehDepartment of Biology, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran.

Alireza KhodavandiDepartment of Biology, Gachsaran Branch, Islamic Azad University, Gachsaran, Iran. alireza_khodavandi@yahoo.com.

Sadegh Nouripour-SisakhtCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

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6 · The paper itself

Abstract

backgroundMenthol, a natural quorum sensing molecule, is derived from the Mentha species. Combating pathogenicity by inactivating quorum sensing is an emerging approach. Therefore, our objective was to investigate anti-quorum sensing and anti-biofilm potentials of menthol in Candida albicans and Candida glabrata.

methodsThe antifungal properties of menthol were evaluated using a broth microdilution assay and a time-kill assay, and its effects on quorum sensing-mediated virulence factors, cellular reactive oxygen species (ROS), and biofilm formation were tested by evaluating TUP1 expression levels in both C. albicans and C. glabrata.

resultsQuorum sensing-mediated virulence factors and biofilm formation were inhibited by menthol in both C. albicans and C. glabrata. Furthermore, coinciding with elevated ROS levels, mRNAs of the quorum sensing-related gene TUP1 were upregulated in both C. albicans and C. glabrata.

conclusionsThis study highlights the anti-quorum sensing potential of menthol through the inhibition of quorum sensing-mediated virulence factors, ROS generation, and biofilm development by targeting TUP1, which could have potential in the treatment of Candida infections.

Indexed as

Antifungal AgentsBiofilmsCandida albicansCandida glabrataFungal ProteinsMentholQuorum SensingReactive Oxygen SpeciesGene Expression Regulation, FungalMicrobial Sensitivity TestsRepressor ProteinsVirulence FactorsAntifungal AgentsFungal ProteinsMentholReactive Oxygen SpeciesRepressor ProteinsVirulence FactorsBiofilmCandida albicansCandida glabrataGene expressionMenthol

Identifiers

PMID39485542

DOI10.1007/s11033-024-10054-1

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