Evidence map›Paper›PMID 39485373›Full record

ArticlePharmacogenetics and genomics2025

The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation.

Larisa H Cavallari, J Kevin Hicks, Jai N Patel, Amanda L Elchynski, D Max Smith, Salma A Bargal, Ashley Fleck, Christina L Aquilante, Shayna R Killam, Lauren Lemke and 38 more

Abstract read
In one paragraph

Article in Pharmacogenetics and genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. UGT1A1 and irinotecan: Ready for routine pharmacogenetic care.British journal of clinical pharmacology · 2026
    Article
  3. Article
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Larisa H CavallariDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville.
J Kevin HicksDepartment of Pathology, Moffitt Cancer Center, Tampa, Florida.
Jai N PatelAtrium Health Levine Cancer Institute, Charlotte.
Amanda L ElchynskiDepartment of Pharmacy, Arkansas Children's Hospital, Little Rock, Arkansas.
D Max SmithMedStar Health, Columbia, Maryland.
Salma A BargalDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Ashley FleckDepartment of Pharmacy, Richard L. Roudebush Veterans Affairs Medical Center, Veteran Health Indiana, Indianapolis, Indiana.
Christina L AquilanteDepartment of Pharmaceutical Sciences, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado.
Shayna R KillamL.S. Skaggs Institute for Health Innovation and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana.
Lauren LemkeLifespan, Providence, Rhode Island, USA.
Taichi OchiDepartment of Pharmacotherapy, Epidemiology & Economics, Groningen Research Institute of Pharmacy; and University Library, University of Groningen, Groningen, The Netherlands.
Laura B RamseyDivision of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri.
Cyrine E HaidarDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee.
Teresa HoDepartment of Pathology, Moffitt Cancer Center, Tampa, Florida.
Nihal El RoubyDepartment of Pharmacy, St. Elizabeth HealthCare, Edgewood, Kentucky.
Andrew A MonteRocky Mountain Poison & Drug Safety, Denver Health & Hospital Authority, Denver, Colorado.
Josiah D AllenDepartment of Pharmacy, St. Elizabeth HealthCare, Edgewood, Kentucky.
Amber L BeitelsheesDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
Jeffrey R BishopDepartment of Experimental and Clinical Pharmacology and Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
Chad BousmanDepartment of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.
Ronald CampbellAllegheny General Hospital, Allegheny Health Network, Pittsburgh, Pennsylvania.
Emily J CicaliDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida, Gainesville.
Kelsey J CookDepartment of Pharmacy Education and Practice, University of Florida College of Pharmacy.
Benjamin DuongPrecision Medicine Program, Nemours Children's Health Delaware Valley, Wilmington, Delaware, USA.
Evangelia Eirini TsermpiniPharmacogenetics Laboratory, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Sonya Tang GirdwoodDivisions of Hospital Medicine and Translational and Clinical Pharmacology, Cincinnati Children's Hospital.
David B GregornikPharmacogenomics Program, Children's Minnesota, Minneapolis/St Paul, Minnesota.
Kristin N GrimsrudDepartment of Pathology and Laboratory Medicine, University of California Health, Sacramento, California.
Nathan LambDepartment of Pharmacy, Ann & Robert H. Lurie Children's Hospital of Chicago.
James C LeeDepartment of Pharmacy Practice, University of Illinois at Chicago, Chicago, Illinois, USA.
Rocio Ortiz LopezTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, Mexico.
Tinashe Adrian MazhinduAfrican Institute of Biomedical Sciences & Technology, Harare, Zimbabwe.
Sarah A MorrisAtrium Health Levine Cancer Institute, Charlotte.
Mohamed NagyPersonalised Medication Management Unit, Children's Cancer Hospital Egypt 57357, Cairo, Egypt.
Jenny NguyenPersonalized Care Program, Children's Hospital Los Angeles, Los Angeles, California.
Amy L PasternakDepartment of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan.
Natasha PetrySanford Imagenetics, Sanford Health, Sioux Falls, South Dakota.
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
April SchultzSanford Imagenetics, Sanford Health, Sioux Falls, South Dakota.
Todd C SkaarDivision of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Hana Al AlshaykhPharmaceutical Care Department, King Faisal Specialist Hospital and Research Center, College of Pharmacy, Alfaisal University, Riyadh, Saudi Arabia.
James M StevensonDivision of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Rachael M StoneDepartment of Pharmacy, University of Virginia, Charlottesville, Virginia.
Nam K TranDepartment of Pathology and Laboratory Medicine, University of California Health, Sacramento, California.
Sony TutejaUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Erica L WoodahlL.S. Skaggs Institute for Health Innovation and Department of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, Montana.
Li-Chi YuanProvidence Health and Services, Irvine, California.
Craig R LeeDivision of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Personalizing EmerGency/Acute therapeuticS Utilizing Systems biology (PEGASUS-2)R35GM152157 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI Andrew Albert Monte · 2024 to 2026
$1.2M
Characterizing the Impact of Genetic Polymorphism on Fentanyl Efficacy and Tolerance in PediatricsK01OD026608 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GRIMSRUD, KRISTIN NICOLE · 2019 to 2023
$731k
NIGMS NIH HHS R35 GM152157NIH HHS K01 OD026608NIH HHS L40 OD030193
6 · The paper itself

Abstract

Pharmacogenetics promises to optimize treatment-related outcomes by informing optimal drug selection and dosing based on an individual's genotype in conjunction with other important clinical factors. Despite significant evidence of genetic associations with drug response, pharmacogenetic testing has not been widely implemented into clinical practice. Among the barriers to broad implementation are limited guidance for how to successfully integrate testing into clinical workflows and limited data on outcomes with pharmacogenetic implementation in clinical practice. The Pharmacogenomics Global Research Network Implementation Working Group seeks to engage institutions globally that have implemented pharmacogenetic testing into clinical practice or are in the process or planning stages of implementing testing to collectively disseminate data on implementation strategies, metrics, and health-related outcomes with the use of genotype-guided drug therapy to ultimately help advance pharmacogenetic implementation. This paper describes the goals, structure, and initial projects of the group in addition to implementation priorities across sites and future collaborative opportunities.

Indexed as

PharmacogeneticsHumansPharmacogenomic TestingPrecision Medicine

Identifiers

PMID39485373
PMCPMC11664750

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.