ArticleThe Journal of experimental medicine2024
Auto-Abs neutralizing type I IFNs in patients with severe Powassan, Usutu, or Ross River virus disease.
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Article in The Journal of experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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33citing papers in PubMed, 1 pooled it
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review and Meta-analysis of Anti-interferon Auto-antibodies in Infectious Diseases.Journal of clinical immunology · 2026Pooled it
- Prevalence of neutralizing autoantibodies against type I interferon in dengue patients.Journal of human immunity · 2026Article
- High prevalence of autoantibodies neutralizing type I IFNs in Japanese patients with hepatitis C.Journal of human immunity · 2026Article
- Ross River virus transmission, infection, and disease: two and a half decades of research progress-an updated cross-disciplinary review.Clinical microbiology reviews · 2026Review
- Powassan Virus in the United States: An AI-Integrative One Health Scoping Review of Ecological Drivers, Zoonotic Interactions, Symptom Profiles, and Public Health Implications.Infectious disease reports · 2026Review
- Autoantibodies neutralizing type I interferons underlie a third of cases of Chikungunya virus encephalitis or myelitis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Autoantibodies against type I interferons in patients with zoonotic H7N9 influenza: an observational case-control study.EBioMedicine · 2026Observational
- Article
- Brain endothelial cells orchestrate a neuroprotective antiviral state in the CNS in response to peripheral viral pattern sensing.Immunity · 2026Article
- Endemic progression of autochthonous West Nile virus infections in Europe.European journal of microbiology & immunology · 2026Review
- Affinity-matured B cell responses neutralizing type-I interferons underlie severe viral infections.Cell · 2026Article
- Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts.Journal of human immunity · 2026Article
- Toward a monogenic architecture of human infections: From 1996 to 2026.Journal of human immunity · 2026Review
- RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution.Cellular & molecular immunology · 2026Article
- Human antibodies against West Nile and related orthoflaviviruses.bioRxiv : the preprint server for biology · 2026Article
- High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.medRxiv : the preprint server for health sciences · 2026Article
- Autoantibodies neutralizing type 1 interferons in two cohorts of people with HIV.Journal of human immunity · 2026Article
- Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.The Journal of experimental medicine · 2026Article
- Autoantibodies neutralizing type I IFNs in a fatal case of H5N1 avian influenza.The Journal of experimental medicine · 2026Article
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Authors and funding
38 authors.
Adrian GervaisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-1083-5787
Paul BastardLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-5926-8437
Lucy BizienLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-9163-9122
Céline DeliferÉtablissement Français du Sang , La Plaine Saint-Denis, France.ORCID 0009-0000-6001-8921
Pierre TiberghienÉtablissement Français du Sang , La Plaine Saint-Denis, France.ORCID 0000-0002-9310-8322
Chaturaka RodrigoFaculty of Medicine, School of Biomedical Sciences, UNSW Australia, Sydney, Australia.ORCID 0000-0003-2189-9177
Francesca TrespidiNeonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy.ORCID 0009-0007-7206-6796
Micol AngeliniNeonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy.ORCID 0000-0001-7255-4115
Giada RossiniMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.ORCID 0000-0002-8917-6680
Tiziana LazzarottoMicrobiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.ORCID 0000-0003-3093-363X
Francesca ContiPediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna , Bologna, Italy.ORCID 0000-0002-3665-8926
Irene CassanitiDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.ORCID 0000-0002-3385-2088
Fausto BaldantiDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.ORCID 0000-0002-3358-8969
Francesca RovidaDepartment of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.ORCID 0000-0003-2345-2790
Alessandro FerrariMicrobiology and Virology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.ORCID 0000-0003-2397-7079
Davide MiletoLaboratory of Clinical Microbiology, Virology and Bioemergencies, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.ORCID 0000-0002-9414-0287
Alessandro ManconLaboratory of Clinical Microbiology, Virology and Bioemergencies, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Milan, Italy.ORCID 0000-0002-1490-636X
Laurent AbelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-7016-6493
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0003-2603-0323
Aurélie CobatLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0001-7209-6257
Charles M RiceLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3087-8079
Dániel CadarBernhard Nocht Institute for Tropical Medicine , Hamburg, Germany.ORCID 0000-0002-8063-2766
Jonas Schmidt-ChanasitBernhard Nocht Institute for Tropical Medicine , Hamburg, Germany.ORCID 0000-0003-4433-0231
Johannes F ScheidMassachusetts General Hospital and Harvard Medical School , Boston, MA, USA.ORCID 0009-0002-1140-1611
Jacob E LemieuxMassachusetts General Hospital and Harvard Medical School , Boston, MA, USA.ORCID 0000-0002-2758-4005
Eric S RosenbergMassachusetts General Hospital and Harvard Medical School , Boston, MA, USA.ORCID 0009-0002-3650-7375
Marianna AgudeloLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3924-6449
Stuart G Tangye *Garvan Institute of Medical Research , Darlinghurst, Australia.ORCID 0000-0002-5360-5180
Alessandro Borghesi *Neonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy.ORCID 0000-0002-8773-9144
Guillaume André Durand *National Reference Center for Arboviruses, Inserm-IRBA , Marseille, France.ORCID 0000-0003-3348-9618
Emilie Duburcq-Gury *Intensive Care Unit, Saint Philibert Hospital, Lille Catholic Hospitals, Lille, France.ORCID 0000-0002-6935-0354
Braulio M Valencia *The Kirby Institute, UNSW Australia , Sydney, Australia.ORCID 0000-0001-6741-3908
Andrew R Lloyd *The Kirby Institute, UNSW Australia , Sydney, Australia.ORCID 0000-0001-6277-8887
Anna Nagy *National Reference Laboratory for Viral Zoonoses, National Public Health Center, Budapest, Hungary.ORCID 0000-0002-4081-2308
Margaret M MacDonald *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-5177-2068
Yannick Simonin *Pathogenesis and Control of Chronic and Emerging Infections, University of Montpellier, INSERM, EFS , Montpellier, France.ORCID 0000-0002-3475-1369
Shen-Ying Zhang *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-9449-3672
Jean-Laurent Casanova *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale (INSERM) U1163, Necker Hospital for Sick Children, Paris, France.ORCID 0000-0002-7782-4169
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MVirology CoreP01AI138938 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2018 to 2022
$8.4MUnraveling yellow fever 17D vaccine attenuation: The role of type I interferon and innate immunityR01AI124690 · NIAID · ROCKEFELLER UNIVERSITY · PI Charles M Rice · 2016 to 2026
$8.3MInborn errors of immunity in patients with life-threatening COVID-19R01AI163029 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT, ZHANG, QIAN · 2021 to 2025
$3.7MMicrobial Determinants of Clinical Heterogeneity in Lyme DiseaseR00AI148604 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI LEMIEUX, JACOB ERIC · 2022 to 2023
$500kDiscovery and characterization of human neutralizing antibodies against Powassan virus in patients with Lyme disease for therapy, vaccine, clinical comorbidity profiling, and diagnostic purposes.R21AI142010 · NIAID · ROCKEFELLER UNIVERSITY · PI MACDONALD, MARGARET R · 2019 to 2020
$479kAgence Nationale de la Recherche ANR-10-IAHU-01ANRS-MIE ANRS0348Battersea & Bowery Advisory GroupBettencourt-Schueller FoundationFisher Center for Alzheimer's Research FoundationFondation du SouffleFondazione IRCCS Policlinico San MatteoFrench Foundation for Medical Research EQU201903007798French Ministry of Higher Education, Research, and InnovationGrandir - Fonds de solidarité pour l'enfanceHoward Hughes Medical InstituteImagine InstituteInstitut National de la Santé et de la Recherche MédicaleItalian Ministry of Health RC08061819JPB FoundationMeyer FoundationNational Health and Medical Research Council 1176665National Health and Medical Research Council of Australia 1176665NCATS NIH HHS UL1 TR001866NIAID NIH HHS P01 AI138938NIAID NIH HHS R00 AI148604NIAID NIH HHS R01 AI124690NIAID NIH HHS R01 AI163029NIAID NIH HHS R21 AI142010NIH HHS R01AI163029Paris Cité UniversityRockefeller UniversitySan Matteo Hospital 08061821SCOR Corporate Foundation for ScienceSquare FoundationStavros Niarchos FoundationSt. Giles Foundation
Abstract
Arboviral diseases are a growing global health concern. Pre-existing autoantibodies (auto-Abs) neutralizing type I interferons (IFNs) can underlie encephalitis due to West Nile virus (WNV) (∼40% of patients) and tick-borne encephalitis (TBE, due to TBE virus [TBEV]) (∼10%). We report here that these auto-Abs can also underlie severe forms of rarer arboviral infections. Auto-Abs neutralizing high concentrations of IFN-α2, IFN-β, and/or IFN-ω are present in the single case of severe Powassan virus (POWV) encephalitis studied, two of three cases of severe Usutu virus (USUV) infection studied, and the most severe of 24 cases of Ross River virus (RRV) disease studied. These auto-Abs are not found in any of the 137 individuals with silent or mild infections with these three viruses. Thus, auto-Abs neutralizing type I IFNs underlie an increasing list of severe arboviral diseases due to Flaviviridae (WNV, TBEV, POWV, USUV) or Togaviridae (RRV) viruses transmitted to humans by mosquitos (WNV, USUV, RRV) or ticks (TBEV, POWV).
Indexed as
Alphavirus InfectionsAntibodies, NeutralizingAutoantibodiesEncephalitis, Tick-BorneEncephalitis Viruses, Tick-BorneInterferon Type IRoss River virusAdultAgedFemaleFlavivirusHumansMaleMiddle AgedRoss River Virus InfectionAntibodies, NeutralizingAutoantibodiesInterferon Type I
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