Evidence map›Paper›PMID 39485283›Full record

ArticleeLife2024

FGF8-mediated gene regulation affects regional identity in human cerebral organoids.

Michele Bertacchi, Gwendoline Maharaux, Agnès Loubat, Matthieu Jung, Michèle Studer

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. FGF family in health and disease.Molecular biomedicine · 2026
    Review
  6. Spatial architecture of development and disease.Nature reviews. Genetics · 2026
    Review
  7. Organoids for disease modeling and treatment: state-of-the-art.Experimental hematology & oncology · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michele BertacchiUniv. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France.ORCID https://orcid.org/0000-0002-4402-4974
Gwendoline MaharauxUniv. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France.ORCID https://orcid.org/0009-0006-7076-5887
Agnès LoubatUniv. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France.
Matthieu JungGenomEast platform, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.ORCID https://orcid.org/0000-0002-3272-7322
Michèle StuderUniv. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France.ORCID https://orcid.org/0000-0001-7105-2957

Funding

Agence Nationale de la Recherche ANR-10-INBS-0009Agence Nationale de la Recherche ANR-21-NEU2-0003-03Agence Nationale de la Recherche IDEX UCAJedi ANR-15-IDEX-01ERA-NET NEURON JTC21 - Agence Nationale de la Recherche ANR-21-NEU2-0003-03Fondation de France 00123416Fondation pour la Recherche Médicale EQU202003010222Institut National de la Santé et de la Recherche Médicale Dotation exceptionnelle prise de fonctions
6 · The paper itself

Abstract

The morphogen FGF8 establishes graded positional cues imparting regional cellular responses

Indexed as

Fibroblast Growth Factor 8OrganoidsCell DifferentiationGene Expression RegulationGene Expression Regulation, DevelopmentalHumansInduced Pluripotent Stem CellsNeural Stem CellsNeuronsSignal TransductionFGF8 protein, humanFibroblast Growth Factor 8developmental biologydorsoventral identityFGF8hIPSChumanLGE-derived interneuronsmulti-regional cerebral organoidsnetwork activityneurodevelopmental disease genesNR2F1

Identifiers

PMID39485283
PMCPMC11581432

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.