Evidence map›Paper›PMID 39485113›Full record

Trial reportRadiology. Imaging cancer2024

Safety and Feasibility of Interventional Hybrid Fluoroscopy and Nuclear Imaging in the Work-up Procedure of Hepatic Radioembolization.

Martijn M A Dietze, Marjolein B M Meddens, Rob van Rooij, Arthur J A T Braat, Bart de Keizer, Rutger C G Bruijnen, Marnix G E H Lam, Maarten L J Smits, Hugo W A M de Jong

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Radiology. Imaging cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06013774 (Interventional X-ray and Scintigraphy Imaging of 99mTc-MAA During the Radioembolisation Pretreatment Procedure), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06013774 nacompletednot on this map

Interventional X-ray and Scintigraphy Imaging of 99mTc-MAA During the Radioembolisation Pretreatment Procedure

TypeinterventionalSponsorUMC UtrechtRan2021 to 2023Enrolled12ConditionsLiver CancerArmsIXSI
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Optimization ofEJNMMI physics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martijn M A DietzeFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.ORCID 0000-0003-1159-3510
Marjolein B M MeddensFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.
Rob van RooijFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.
Arthur J A T BraatFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.ORCID 0000-0002-8824-8697
Bart de KeizerFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.
Rutger C G BruijnenFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.
Marnix G E H LamFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.ORCID 0000-0002-4902-9790
Maarten L J SmitsFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.ORCID 0000-0003-4735-655X
Hugo W A M de JongFrom the Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, PO Box 85500, 3508 GA Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To evaluate the safety and feasibility of a novel hybrid nuclear and fluoroscopy C-arm scanner to be used during the work-up procedure of hepatic radioembolization. Materials and Methods In this prospective first-in-human clinical study, 12 participants (median age, 67 years [range: 37-78 years]; nine [75%] male, three [25%] female) with liver tumors undergoing work-up for yttrium 90 radioembolization were included (ClinicalTrials.gov NCT06013774). Work-up angiography and technetium 99m-macroaggregated albumin injection were performed in an angiography suite equipped with a hybrid C-arm that could simultaneously perform fluoroscopy and planar nuclear imaging. Technetium 99m-macroaggregated albumin was injected under real-time hybrid imaging, followed by in-room SPECT imaging. Safety and feasibility were studied by assessing adverse events, technical performance, additional x-ray radiation dose, and questionnaires completed by radiologists and technologists. Results No adverse events were attributed to the hybrid C-arm scanner. The additional x-ray radiation dose was low (median, 19 Gy · cm

Indexed as

Embolization, TherapeuticFeasibility StudiesLiver NeoplasmsYttrium RadioisotopesAdultAgedAngiographyFemaleFluoroscopyHumansMaleMiddle AgedProspective StudiesRadiopharmaceuticalsTechnetium Tc 99m Aggregated AlbuminTomography, Emission-Computed, Single-PhotonRadiopharmaceuticalsTechnetium Tc 99m Aggregated AlbuminYttrium-90Yttrium RadioisotopesAngiographyCyberknifeFluoroscopyGamma KnifeInstrumentationInterventional-VascularPhysicsRadionuclide StudiesRadiosurgerySPECTTechnical AspectsTechnology Assessment

Identifiers

PMID39485113
PMCPMC11615633

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.