Evidence map›Paper›PMID 39484843›Full record

ArticleThe Journal of clinical endocrinology and metabolism2025

Human Peripancreatic Adipose Tissue Paracrine Signaling Impacts Insulin Secretion, Blood Flow, and Gene Transcription.

Bryan C Bergman, Karin Zemski Berry, Amanda Garfield, Amy Keller, Simona Zarini, Sophia Bowen, Colleen McKenna, Darcy Kahn, Jay Pavelka, Emily Macias and 11 more

Abstract read
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In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Human Peripancreatic Fat Secretome Impacts Local Pancreas Biology.The Journal of clinical endocrinology and metabolism · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Bryan C BergmanSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-9561-1052
Karin Zemski BerrySchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Amanda GarfieldSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Amy KellerSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Simona ZariniSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Sophia BowenSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Colleen McKennaSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Darcy KahnSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Jay PavelkaSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Emily MaciasSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Charis UhlsonSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Chris JohnsonSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Holger A RussCollege of Medicine, Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL 32610, USA.
Carlos H ViesiDepartment of Biological Chemistry and the Center for Epigenetics and Metabolism, University of California, Irvine, CA 92617, USA.
Marcus SeldinDepartment of Biological Chemistry and the Center for Epigenetics and Metabolism, University of California, Irvine, CA 92617, USA.ORCID 0000-0001-8026-4759
Chengyang LiuInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Nicolai M DolibaInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jonathan SchoenDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kevin RothchildDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kweku HazelDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Ali NajiInstitute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Funding

Intermuscular adipose tissue (IMAT): protagonist in sarcopenia and insulin resistance in humansR01DK118149 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BERGMAN, BRYAN C · 2018 to 2022
$2.9M
Human Islet Research Network SCR 014393Human Pancreas Analysis Program SCR 016202National Institutes of Health General Clinical Research Center RR-00036NIDDK NIH HHS R01 DK118149
6 · The paper itself

Abstract

contextAdipose tissue accumulation around nonadipose tissues is associated with obesity and metabolic disease. One relatively unstudied depot is peripancreatic adipose tissue (PAT) that accumulates in obesity and insulin resistance and may impact β-cell function. Pancreatic lipid accumulation and PAT content are negatively related to metabolic outcomes in humans, but these studies are limited by the inability to pursue mechanisms.

objectiveWe obtained PAT from human donors through the Human Pancreas Analysis Program to evaluate differences in paracrine signaling compared to subcutaneous adipose tissue (SAT), as well as effects of the PAT secretome on aortic vasodilation, human islet insulin secretion, and gene transcription using RNA sequencing.

resultsPAT had greater secretion of interferon-γ and most inflammatory eicosanoids compared to SAT. Secretion of adipokines negatively related to metabolic health were also increased in PAT compared to SAT. We found no overall effects of PAT compared to SAT on human islet insulin secretion; however, insulin secretion was suppressed after PAT exposure from men compared to women. Vasodilation was significantly dampened by PAT conditioned media, an effect explained almost completely by PAT from men and not women. Islets treated with PAT showed selective changes in lipid metabolism pathways while SAT altered cellular signaling and growth. RNA sequencing analysis showed changes in islet gene transcription impacted by PAT compared to SAT, with the biggest changes found between PAT based on sex.

conclusionThe PAT secretome is metabolically negative compared to SAT, and impacts islet insulin secretion, blood flow, and gene transcription in a sex-dependent manner.

Indexed as

Adipose TissueInsulinInsulin SecretionPancreasParacrine CommunicationTranscription, GeneticAdultFemaleHumansIslets of LangerhansMaleMiddle AgedSubcutaneous FatVasodilationInsulinadipose secretomebeta cellsectopic adipose tissuehuman isletsinsulin secretionobesity

Identifiers

PMID39484843

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.