Evidence map›Paper›PMID 39484667›Full record

ArticleNeuroSci2022

Sialic Acid Ameliorates Cognitive Deficits by Reducing Amyloid Deposition, Nerve Fiber Production, and Neuronal Apoptosis in a Mice Model of Alzheimer's Disease.

Min Xiao, Chuangyu Yao, Fang Liu, Wei Xiang, Yao Zuo, Kejue Feng, Shuhuan Lu, Li Xiang, Muzi Li, Xiangyu Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroSci, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Effects of extracts and manna ofResearch in pharmaceutical sciences · 2024
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min XiaoR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).
Chuangyu YaoGuangdong Provincial Key Laboratory for Plant Epigenetics, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; 1900251019@email.szu.edu.cn.
Fang LiuR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).ORCID https://orcid.org/0000-0001-7941-0026
Wei XiangR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).ORCID https://orcid.org/0000-0001-6926-7799
Yao ZuoR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).ORCID https://orcid.org/0000-0002-4888-8024
Kejue FengR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).
Shuhuan LuR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).
Li XiangR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).
Muzi LiR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).
Xiangyu LiR&D Center, Cabio Biotech (Wuhan) Co., Ltd., No. 999 Gaoxin Rd., Wuhan 430073, China; min_xiao@cabio.cn (M.X.); fayn_liu@cabio.cn (F.L.); wei_xiang@cabio.cn (W.X.); freya_zuo@cabio.cn (Y.Z.); kejue_feng@cabio.cn (K.F.); sophia_lu@cabio.cn (S.L.); alison_xiang@cabio.cn (L.X.); muzi_li@cabio.cn (M.L.).
Xiubo DuShenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: As a natural carbohydrate, sialic acid (SA) is helpful for brain development, cognitive ability, and the nervous system, but there are few reports about the effect of SA on Alzheimer's disease (AD). (2) Method: The present study evaluated the effect of SA on cognitive ability, neuronal activity, Aβ formation, and tau hyperphosphorylation in a double transgenic AD (2×Tg-AD) mice model. The 2×Tg-AD mice were randomly divided into four groups: the AD control group, 17 mg/kg SA-treated AD group, 84 mg/kg SA-treated AD group, and 420 mg/kg SA-treated AD group. Mice from all four groups were fed to 7 months of age for the behavioral test and to 9 months of age for the pathological factors investigation. (3) Results: In the Morris water maze, the escape latency significantly decreased on the fifth day in the SA-treated groups. The number of rearing and crossing times in the open field test also increased significantly, compared with the control group. SA treatment significantly reduced amyloid β-peptide (Aβ) and nerve fibers and increased the number of Nissl bodies in the brain of AD mice. (4) Conclusions: SA reduced the neuron damage by reducing Aβ and inhibited tau protein hyperphosphorylation, which improved the cognitive ability and mobility of AD mice.

Indexed as

Alzheimer’s diseaseneurodegenerative diseasesialic acid

Identifiers

PMID39484667
PMCPMC11523747

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