Evidence map›Paper›PMID 39484621›Full record

ArticlebioRxiv : the preprint server for biology2024

Wideband ratiometric measurement of tonic and phasic dopamine release in the striatum.

Amy Gottschalk, Haley Menees, Celine Bogner, Semele Zewde, Joanna Jibin, Asma Gamam, Dylan Flink, Meea Mosissa, Faith Bonneson, Hibo Wehelie and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Amy GottschalkDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Haley MeneesDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Celine BognerDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Semele ZewdeDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Joanna JibinDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Asma GamamDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Dylan FlinkDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Meea MosissaDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Faith BonnesonDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Hibo WehelieDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.
Yanaira Alonso-CaraballoDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.ORCID 0000-0002-7553-4408
Arif A HamidDepartment of Neuroscience, University of Minnesota - Twin Cities, Minneapolis, MN.ORCID 0000-0001-7403-0067

Funding

NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
A Longitudinal Mentoring Approach to Increase Diversity-RenewalR25NS117356 · NINDS · UNIVERSITY OF MINNESOTA · PI Angeline Joan Dukes, Paul G Mermelstein · 2020 to 2026
$1.6M
NIDA NIH HHS T32 DA007234NINDS NIH HHS R25 NS117356
6 · The paper itself

Abstract

Reward learning, cognition, and motivation are supported by changes in neurotransmitter levels across multiple timescales. Current measurement technologies for various neuromodulators (such as dopamine and serotonin) do not bridge timescales of fluctuations, limiting the ability to define the behavioral significance, regulation, and relationship between fast (phasic) and slow (tonic) dynamics. To help resolve longstanding debates about the behavioral significance of dopamine across timescales, we developed a novel quantification strategy, augmenting extensively used carbon-fiber Fast Scan Cyclic Voltammetry (FSCV). We iteratively engineered the FSCV scan sequence to rapidly modify electrode sensitivity within a sampling window and applied ratiometric analysis for wideband dopamine measurement. This allowed us to selectively eliminate artifacts unrelated to electrochemical detection (i.e., baseline drift), overcoming previous limitations that precluded wideband dopamine detection from milliseconds to hours. We extensively characterize this approach

Identifiers

PMID39484621
PMCPMC11526850

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.