Evidence map›Paper›PMID 39484577›Full record

ArticlebioRxiv : the preprint server for biology2024

Stoichiometry of HIV-1 Envelope Glycoprotein Protomers with Changes That Stabilize or Destabilize the Pretriggered Conformation.

Zhiqing Zhang, Saumya Anang, Qian Wang, Hanh T Nguyen, Hung-Ching Chen, Ta-Jung Chiu, Derek Yang, Amos B Smith, Joseph G Sodroski

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Zhiqing ZhangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Saumya AnangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Qian WangDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Hanh T NguyenDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Hung-Ching ChenDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Ta-Jung ChiuDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Derek YangDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Amos B SmithDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Joseph G SodroskiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.ORCID 0000-0002-9750-1615

Funding

ERASE HIV: Enterprise for Research and Advancements to Stop and Eradicate HIVUM1AI164562 · NIAID · EMORY UNIVERSITY · PI Deanna A Kulpa, Mirko Paiardini · 2021 to 2026
$30.0M
Understanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01AI150471 · NIAID · DREXEL UNIVERSITY · PI CHAIKEN, IRWIN M, MOTHES, WALTHER H · 2019 to 2022
$7.8M
Conformational Landscape of the HIV-1 Envelope GlycoproteinsR01AI124982 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2016 to 2025
$6.7M
Probing functional HIV-1 envelope glycoprotein conformations with novel potent CD4-mimetic compoundsR01AI176904 · NIAID · DANA-FARBER CANCER INST · PI WAYNE A. HENDRICKSON, WALTHER H MOTHES · 2023 to 2026
$3.4M
Combining Molecular Simulations and Biophysical Methods to Characterize Conformational Dynamics of the HIV-1 Envelope GlycoproteinR01AI178833 · NIAID · DREXEL UNIVERSITY · PI CAMERON F ABRAMS, WALTHER H MOTHES · 2023 to 2026
$3.2M
Enrichment of the State-1 Conformation of the HIV-1 Envelope GlycoproteinR01AI145547 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2019 to 2021
$2.2M
Reducing viral reservoirs by opening HIV-1 Env to antibody attackR33AI129017 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2019 to 2021
$1.6M
Reducing viral reservoirs by opening HIV-1 Env to antibody attackR21AI129017 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2017 to 2018
$459k
NIAID NIH HHS P01 AI150471NIAID NIH HHS R01 AI124982NIAID NIH HHS R01 AI145547NIAID NIH HHS R01 AI176904NIAID NIH HHS R01 AI178833NIAID NIH HHS R21 AI129017NIAID NIH HHS R33 AI129017NIAID NIH HHS UM1 AI164562
6 · The paper itself

Abstract

During human immunodeficiency virus (HIV-1) entry into host cells, binding to the receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer ((gp120-gp41)

Indexed as

CD4-mimetic compoundcold inactivationEnvgp120gp41Human immunodeficiency virusmutationState 1subunit interactiontrimer

Identifiers

PMID39484577
PMCPMC11527345

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.