Evidence map›Paper›PMID 39484571›Full record

ArticlebioRxiv : the preprint server for biology2024

40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.

Abigail L Paulson, Lu Zhang, Ashley M Prichard, Annabelle C Singer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Abigail L PaulsonCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Lu ZhangCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, 30332, USA.
Ashley M PrichardCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID 0000-0001-7666-1444
Annabelle C SingerCoulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, 30332, USA.ORCID 0000-0001-6003-0488

Funding

TRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5M
Non-Invasive Methods to Drive Neural Activity with Millisecond Precision and to Recruit the Brain’s Immune CellsR01NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI Annabelle Catherine Singer · 2018 to 2026
$2.7M
Hippocampal interneurons in novel memory formation in health and Alzheimer's diseaseRF1AG078736 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2022 to 2025
$2.5M
Gamma Sensory Flicker as an Early Intervention for Alzheimer’s Disease: Mechanisms and Protective EffectsRF1NS109226 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI SINGER, ANNABELLE CATHERINE · 2023 to 2024
$2.2M
Effects of non-invasive gamma stimulation on hippocampal neural codes in a mouse model of Alzheimer’s diseaseF31AG066410 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI PAULSON, ABIGAIL LYNN · 2019 to 2021
$137k
NIA NIH HHS F31 AG066410NIA NIH HHS RF1 AG078736NINDS NIH HHS R01 NS109226NINDS NIH HHS RF1 NS109226NINDS NIH HHS T32 NS007480
6 · The paper itself

Abstract

40 Hz sensory stimulation ("flicker") has emerged as a new technique to potentially mitigate pathology and improve cognition in mouse models of Alzheimer's disease (AD) pathology. However, it remains unknown how 40 Hz flicker affects neural codes essential for memory. Accordingly, we investigate the effects of 40 Hz flicker on neural representations of experience in the hippocampus of the 5XFAD mouse model of AD by recording 1000s of neurons during a goal-directed spatial navigation task. We find that an hour of daily exposure to 40 Hz audio-visual stimulation over 8 days leads to higher coordination between hippocampal subregions CA3 and CA1 during navigation. Consistent with CA3's role in generating sequential activity that represents future positions, 40 Hz flicker exposure increased prospective coding of future positions. In turn, prospective coding was more prominent during efficient navigation behavior. Our findings show how 40 Hz flicker enhances key hippocampal activity during behavior that is important for memory.

Indexed as

Alzheimer’s diseaseBiological SciencesGamma oscillationsHippocampusNeuroscienceNon-invasive brain stimulationProspective CodingReplaySpatial navigation

Identifiers

PMID39484571
PMCPMC11526945

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.