Evidence map›Paper›PMID 39484524›Full record

ArticlebioRxiv : the preprint server for biology2024

Impairment of Neuronal Activity in the Dorsolateral Prefrontal Cortex Occurs Early in Parkinsonism.

Noah Hjelle, Biswaranjan Mohanty, Tanner Hubbard, Matthew D Johnson, Jing Wang, Luke A Johnson, Jerrold L Vitek

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Noah HjelleDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Biswaranjan MohantyDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Tanner HubbardDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Matthew D JohnsonDepartment of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA.
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.

Funding

Deep Brain Stimulation in the Parkinsonian MonkeyR01NS037019 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek · 1999 to 2026
$14.5M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
The Effects of Parkinsonism and Deep Brain Stimulation on Basal Ganglia-Thalamocortical Circuitry During Sleep-Wake BehaviorR01NS110613 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON · 2019 to 2026
$4.7M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
Optimizing coordinated reset deep brain stimulation for Parkinson's diseaseR01NS117822 · NINDS · UNIVERSITY OF MINNESOTA · PI WANG, JING · 2020 to 2024
$3.0M
NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS037019NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS110613NINDS NIH HHS R01 NS117822NINDS NIH HHS R37 NS077657
6 · The paper itself

Abstract

Background: Parkinson's disease (PD) is often characterized by altered rates and patterns of neuronal activity in the sensorimotor regions of the basal ganglia thalamocortical network. Little is known, however, regarding how neuronal activity in the executive control network of the brain changes in the parkinsonian condition. Objective: Investigate the impact of parkinsonism on neuronal activity in the dorsolateral prefrontal cortex (DLPFC), a key region in executive control, during a go/nogo reaching task. Methods: Using a within-subject design, single and multi-unit neuronal activity was recorded in the DLPFC of a nonhuman primate before and after the induction of mild parkinsonism using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Results: Coincident with development of mild parkinsonian motor signs, there was a marked reduction in the percentage of DLPFC cells with significant task-related firing rate modulation during go and nogo conditions. Conclusions: These results suggest that DLPFC dysfunction may occur early in parkinsonism and contribute to cognitive impairments and disrupted executive function often observed in PD patients.

Identifiers

PMID39484524
PMCPMC11527011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.