Evidence map›Paper›PMID 39484515›Full record

ArticlebioRxiv : the preprint server for biology2024

Distinct maternofetal immune signatures delineate preterm birth onset following urinary tract infection.

Samantha Ottinger, Addison B Larson, Vicki Mercado-Evans, Holly Branthoover, Jacob J Zulk, Camille Serchejian, Marlyd E Mejia, Zainab A Hameed, Ryan Walde, Rachel C Fleck and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samantha OttingerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-3439-6376
Addison B LarsonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Vicki Mercado-EvansDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-9421-9131
Holly BranthooverDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0001-7808-1662
Jacob J ZulkDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-3758-5503
Camille SerchejianDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Marlyd E MejiaDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-4929-6450
Zainab A HameedDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
Ryan WaldeDepartment of Pathology, University of South Alabama, Mobile, Alabama, USA.
Rachel C FleckDepartment of Microbiology and Immunology, University of South Alabama.
Allyson E SheaDepartment of Microbiology and Immunology, University of South Alabama.ORCID 0000-0003-1329-3888
Kathryn A PatrasDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-2631-8810

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael T. Lewis · 2007 to 2026
$73.9M
Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
Contribution of immune modulation, metabolism, and microbiota to Group B Streptococcal urinary tract infectionR01DK128053 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI PATRAS, KATY · 2021 to 2025
$2.3M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Characterizing the Impact of Gestational Diabetes on Immunity and Group B Streptococcal Virulence in the Maternal Reproductive TractF31AI167547 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MERCADO, VICKI · 2022 to 2025
$178k
Characterizing the impact of maternal immune response to urinary tract infection on preterm birthF31HD111236 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI OTTINGER, SAMANTHA · 2023 to 2025
$149k
Determining the role of the vaginal microbiota in microbial and immunological resistance to vaginal pathobiont colonizationF31AI167538 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI MEJIA, MARLYD ELIZABETH · 2022 to 2024
$143k
Investigating phage therapy for the treatment of urinary tract infectionsF31DK136201 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI ZULK, JACOB JEFFREY · 2023 to 2024
$97k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS F31 AI167538NIAID NIH HHS F31 AI167547NIAID NIH HHS T32 AI055449NICHD NIH HHS F31 HD111236NIDDK NIH HHS F31 DK136201NIDDK NIH HHS R01 DK128053
6 · The paper itself

Abstract

Preterm birth is the leading cause of infant mortality resulting in over one million neonatal deaths annually. Maternal urinary tract infection (UTI) during pregnancy increases risk for preterm birth; however, biological processes mediating UTI-associated preterm birth are not well-described. We established a murine maternal UTI model in which challenge with uropathogenic

Indexed as

IL-10maternal immunitypreterm birthurinary tract infectionuropathogenic E. coli

Identifiers

PMID39484515
PMCPMC11527006

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.