Evidence map›Paper›PMID 39484495›Full record

ArticlebioRxiv : the preprint server for biology2024

Optical control of sphingolipid biosynthesis using photoswitchable sphingosines.

Matthijs Kol, Alexander J E Novak, Johannes Morstein, Christian Schröer, Tolulope Sokoya, Svenja Mensing, Sergei M Korneev, Dirk Trauner, Joost C M Holthuis

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Matthijs KolMolecular Cell Biology Division, Department of Biology/Chemistry, Osnabrück University, 49076 Osnabrück, Germany.ORCID 0000-0003-3068-6501
Alexander J E NovakDepartment of Chemistry, New York University 100 Washington Square East, New York, NY, 10003, USA.ORCID 0000-0002-3619-018X
Johannes MorsteinDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.ORCID 0000-0002-6940-288X
Christian SchröerMolecular Cell Biology Division, Department of Biology/Chemistry, Osnabrück University, 49076 Osnabrück, Germany.ORCID 0000-0003-2773-0567
Tolulope SokoyaMolecular Cell Biology Division, Department of Biology/Chemistry, Osnabrück University, 49076 Osnabrück, Germany.ORCID 0000-0002-0398-4450
Svenja MensingMolecular Cell Biology Division, Department of Biology/Chemistry, Osnabrück University, 49076 Osnabrück, Germany.ORCID 0000-0003-1844-9589
Sergei M KorneevMolecular Cell Biology Division, Department of Biology/Chemistry, Osnabrück University, 49076 Osnabrück, Germany.ORCID 0000-0002-1273-5819
Dirk TraunerDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA, 19104, USA.ORCID 0000-0002-6782-6056
Joost C M HolthuisMolecular Cell Biology Division, Department of Biology/Chemistry, Osnabrück University, 49076 Osnabrück, Germany.ORCID 0000-0001-8912-1586

Funding

Optical Control of the Actin CytoskeletonR01GM126228 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI DIRK HARTWIG TRAUNER · 2018 to 2026
$2.6M
NIGMS NIH HHS R01 GM126228
6 · The paper itself

Abstract

Sphingolipid metabolism comprises a complex interconnected web of enzymes, metabolites and modes of regulation that influence a wide range of cellular and physiological processes. Deciphering the biological relevance of this network is challenging as numerous intermediates of sphingolipid metabolism are short-lived molecules with often opposing biological activities. Here, we introduce clickable, azobenzene-containing sphingosines, termed

Indexed as

azobenzenebudding yeastcell-free expressionceramide synthasechemical synthesisclick chemistrylipidomicsmetabolic labelingphoto-isomerizationsphingomyelin

Identifiers

PMID39484495
PMCPMC11527141

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.