Evidence map›Paper›PMID 39484491›Full record

ArticlebioRxiv : the preprint server for biology2024

Spatiotemporal lineage tracing reveals the dynamic spatial architecture of tumor growth and metastasis.

Matthew G Jones, Dawei Sun, Kyung Hoi Joseph Min, William N Colgan, Luyi Tian, Jackson A Weir, Victor Z Chen, Luke W Koblan, Kathryn E Yost, Nicolas Mathey-Andrews and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Matthew G JonesCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
Dawei SunBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Kyung Hoi Joseph MinWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID 0000-0003-0894-4017
William N ColganWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Luyi TianBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jackson A WeirBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Victor Z ChenDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York City, NY, USA.
Luke W KoblanWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Kathryn E YostWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Nicolas Mathey-AndrewsDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Andrew J C RussellBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5411-2807
Robert R StickelsBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Karol S BalderramaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
William M RideoutDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
Tyler JacksDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Fei ChenBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2308-3649
Jonathan S WeissmanWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Nir YosefDepartment of Systems Immunology, Weizmann Institute of Science, 234 Herzl Street, Rehovot 7610001, Israel.
Dian YangDepartment of Molecular Pharmacology and Therapeutics, Columbia University, New York City, NY, USA.

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Darrell J Irvine · 1985 to 2026
$93.9M
COVID19 Slide-seqR01HG010647 · NHGRI · BROAD INSTITUTE, INC. · PI Fei Chen, Evan Z Macosko · 2019 to 2026
$6.0M
Studying factors controlling cancer progression and immune recognition in mouse modelsR35CA274464 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TYLER E. JACKS · 2022 to 2026
$4.6M
Characterizing glioma heterogeneity with novel multiplexed nanoscale imaging technologiesDP5OD024583 · OD · BROAD INSTITUTE, INC. · PI CHEN, FEI · 2017 to 2021
$2.2M
Towards a Comprehensive, Spatiotemporal Roadmap of Cancer MetastasisDP2CA301079 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI YANG, DIAN · 2024 to 2024
$1.5M
Investigating the cell intrinsic and extrinsic mechanisms governing lung cancer cell plasticityK22CA289207 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dian Yang · 2024 to 2026
$526k
Tumor and Immune Cell Dynamics during Immunotherapy and Cancer ProgressionK00CA253729 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI YOST, KATHRYN ELIZABETH · 2021 to 2024
$401k
Quantitative modeling of extrachromosomal DNA (ecDNA) evolution in tumorsK99CA286968 · NCI · STANFORD UNIVERSITY · PI JONES, MATTHEW GREGORY · 2024 to 2025
$335k
Scalable Computational Methods for Genealogical Inference: from species level to single cellsR56HG013117 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI HOLMES, IAN H, NIELSEN, RASMUS · 2023 to 2023
$315k
Investigating splicing-derived antigens in the context of Rbm10-mutant lung adenocarcinomaF30CA278495 · NCI · HARVARD MEDICAL SCHOOL · PI Nicolas Mathey-Andrews · 2023 to 2026
$216k
NCI NIH HHS DP2 CA301079NCI NIH HHS F30 CA278495NCI NIH HHS K00 CA253729NCI NIH HHS K22 CA289207NCI NIH HHS K99 CA286968NCI NIH HHS P30 CA014051NCI NIH HHS R35 CA274464NHGRI NIH HHS R01 HG010647NHGRI NIH HHS R56 HG013117NIH HHS DP5 OD024583
6 · The paper itself

Abstract

Tumor progression is driven by dynamic interactions between cancer cells and their surrounding microenvironment. Investigating the spatiotemporal evolution of tumors can provide crucial insights into how intrinsic changes within cancer cells and extrinsic alterations in the microenvironment cooperate to drive different stages of tumor progression. Here, we integrate high-resolution spatial transcriptomics and evolving lineage tracing technologies to elucidate how tumor expansion, plasticity, and metastasis co-evolve with microenvironmental remodeling in a

Identifiers

PMID39484491
PMCPMC11526908

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.