Evidence map›Paper›PMID 39484487›Full record

ArticlebioRxiv : the preprint server for biology2024

Abundant genetic variation is retained in many laboratory schistosome populations.

Kathrin S Jutzeler, Roy N Platt, Robbie Diaz, Madison Morales, Winka LE Clec'h, Frédéric D Chevalier, Timothy J C Anderson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kathrin S JutzelerHost parasite Interaction Program, Texas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.ORCID 0000-0002-3687-4020
Roy N PlattDisease Intervention and Prevention program, Texas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.ORCID 0000-0002-9754-5765
Robbie DiazTexas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.
Madison MoralesTexas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.ORCID 0000-0002-9975-3031
Winka LE Clec'hHost parasite Interaction Program, Texas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.ORCID 0000-0002-1111-2492
Frédéric D ChevalierHost parasite Interaction Program, Texas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.ORCID 0000-0003-2611-8106
Timothy J C AndersonDisease Intervention and Prevention program, Texas Biomedical Research Institute, P.O. Box 760549, 78245 San Antonio, Texas, USA.ORCID 0000-0002-0191-0204

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Genomic consequences of schistosome hybridizationR01AI166049 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2021 to 2025
$3.1M
Genetic analysis of cercarial release in schistosomesR01AI133749 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI ANDERSON, TIM J · 2017 to 2021
$2.5M
Graduate Research in Immunology Program (GRIP): To train graduate students for successful careers in academia, industry and governmentT32AI138944 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2018 to 2022
$561k
Role of the microbiome of the schistosome snail hostR21AI171601 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI CHEVALIER, FREDERIC DAVID, LE CLEC'H, WINKA MAI · 2022 to 2023
$545k
MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATIONC06RR013556 · NCRR · SOUTHWEST FOUNDATION FOR BIOMEDICAL RES · PI SHADE, ROBERT E · 1998 to 1998
–
NCRR NIH HHS C06 RR013556NIAID NIH HHS HHSN272201700014CNIAID NIH HHS R01 AI133749NIAID NIH HHS R01 AI166049NIAID NIH HHS R21 AI171601NIAID NIH HHS T32 AI138944NIH HHS P51 OD011133
6 · The paper itself

Abstract

Schistosomes are obligately sexual blood flukes that can be maintained in the laboratory using freshwater snails as intermediate and rodents as definitive hosts. The genetic composition of laboratory schistosome populations is poorly understood: whether genetic variation has been purged due to serial inbreeding or retained is unclear. We sequenced 19 - 24 parasites from each of five laboratory

Indexed as

effective population sizegenetic diversitygenome-wide association studies (GWAS)genomic variationlinkage disequilibriumSchistosoma mansoni

Identifiers

PMID39484487
PMCPMC11526883

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.