Evidence map›Paper›PMID 39484455›Full record

ArticlebioRxiv : the preprint server for biology2025

T cell epitope mapping reveals immunodominance of evolutionarily conserved regions within SARS-CoV-2 proteome.

Cansu Cimen Bozkus, Matthew Brown, Leandra Velazquez, Marcus Thomas, Eric A Wilson, Timothy O'Donnell, Denis Ruchnewitz, Douglas Geertz, Yonina Bykov, Julia Kodysh and 29 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors.

Cansu Cimen BozkusTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7834-4792
Matthew BrownTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Leandra VelazquezTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marcus ThomasDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric A WilsonTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Timothy O'DonnellTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Denis RuchnewitzInstitute for Biological Physics, University of Cologne, 50937 Cologne, Germany.
Douglas GeertzTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yonina BykovGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Julia KodyshTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kasopefoluwa Y OguntuyoThe Department of Medicine, The Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7824-2892
Vladimir RoudkoDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
David HoyosComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Komal D SrivastavaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Giulio KleinerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hala AlshammaryDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Neha KarekarTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christopher McClainTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ramya GopalTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kai NieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Diane Del ValleGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniela Delbeau-ZagelbaumTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Denise RodriguezTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jessica SetalTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai COVID-19 Biobank Team
Emily CarrollThe Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Margrit WiesendangerThe Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Percio S GulkoThe Department of Medicine, The Division of Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander CharneyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8135-6858
Miriam MeradDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seunghee Kim-SchulzeDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benhur LeeDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0760-1709
Ania WajnbergThe Department of Medicine, The Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Viviana SimonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benjamin D GreenbaumComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Diego ChowellTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicolas VabretDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Marta LukszaDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nina BhardwajTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
NCI NIH HHS P30 CA008748NIAID NIH HHS T32 AI007647
6 · The paper itself

Abstract

As SARS-CoV-2 variants continue to emerge capable of evading neutralizing antibodies, it has become increasingly important to fully understand the breadth and functional profile of T cell responses to determine their impact on the immune surveillance of variant strains. Here, sampling healthy individuals, we profiled the kinetics and polyfunctionality of T cell immunity elicited by mRNA vaccination. Modeling of anti-spike T cell responses against ancestral and variant strains of SARS-CoV-2 suggested that epitope immunodominance and cross-reactivity are major predictive determinants of T cell immunity. To identify immunodominant epitopes across the viral proteome, we generated a comprehensive map of CD4

Identifiers

PMID39484455
PMCPMC11527131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.