Evidence map›Paper›PMID 39484448›Full record

ArticlebioRxiv : the preprint server for biology2024

Integrin alpha1 beta1 promotes interstitial fibrosis in a mouse model of polycystic kidney disease.

C Grenier, I-H Lin, Djm Peters, A Pozzi, R Lennon, R W Naylor

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

C GrenierManchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom.
I-H LinBioinformatics Core Facility, Faculty of Biology Medicine and Health, University of Manchester, Manchester, United Kingdom.ORCID 0000-0002-6207-1299
Djm PetersDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0001-6974-7143
A PozziDepartment of Medicine, Division of Nephrology and Hypertension.ORCID 0000-0001-8502-1481
R LennonManchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-6400-0227
R W NaylorManchester Cell-Matrix Centre, Division of Cell-Matrix Biology and Regenerative Medicine, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester, United Kingdom.ORCID 0000-0003-2901-7677

Funding

Matrix receptors in chronic kidney diseaseR01DK119212 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BORZA, CORINA MARILENA, POZZI, AMBRA · 2018 to 2022
$1.7M
Role of Collagen Binding Receptors in GlomerulosclerosisI01BX002025 · VA · VETERANS HEALTH ADMINISTRATION · PI AMBRA POZZI · 2013 to 2026
–
BLR&D Merit Review Research Career Scientist (RCS) Award (IK6)IK6BX005240 · VA · VETERANS HEALTH ADMINISTRATION · PI POZZI, AMBRA · 2020 to 2025
–
BLRD VA I01 BX002025BLRD VA IK6 BX005240NIDDK NIH HHS R01 DK119212Wellcome Trust
6 · The paper itself

Abstract

Fibrosis is the cause of end-stage kidney failure in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The molecular and cellular mechanisms involved in fibrosis are complex and anti-fibrotic therapies have so far failed to make an impact on patient welfare. Using unbiased proteomics analysis on the

Identifiers

PMID39484448
PMCPMC11526950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.