Evidence map›Paper›PMID 39484428›Full record

ArticlebioRxiv : the preprint server for biology2024

Human-mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome.

Jay M Yarbro, Xian Han, Abhijit Dasgupta, Ka Yang, Danting Liu, Him K Shrestha, Masihuz Zaman, Zhen Wang, Kaiwen Yu, Dong Geun Lee and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

31 authors.

Jay M YarbroDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-1793-5630
Xian HanDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-3802-6420
Abhijit DasguptaDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-6302-3512
Ka YangDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-8937-7397
Danting LiuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-8662-5305
Him K ShresthaDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0001-9686-357X
Masihuz ZamanDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-3610-929X
Zhen WangDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kaiwen YuCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-6050-8477
Dong Geun LeeDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-3668-0485
David VanderwallDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-0206-0053
Mingming NiuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Huan SunDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Boer XieCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ping-Chung ChenDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-5982-2434
Yun JiaoDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xue ZhangDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zhiping WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yingxue FuCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Yuxin LiCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zuo-Fei YuanCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xusheng WangDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.
Suresh PoudelCenter for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Barbora VagnerovaDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Qianying HeDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Andrew TangDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Patrick T RonaldsonDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Rui ChangDepartment of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA.
Gang YuDepartment of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-4932-5757
Yansheng LiuDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0002-2626-3912
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Funding

Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI DAVID M. HOLTZMAN · 2021 to 2026
$42.0M
Utilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J · 2019 to 2023
$14.5M
Systems Approaches to Novel Molecular Mechanism in Alzheimer's DiseaseRF1AG064909 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PENG, JUNMIN, YU, GANG · 2019 to 2024
$6.4M
Dissecting neuron-microglia-astrocyte interaction in AD pathogenesisRF1AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2020 to 2023
$5.4M
Multi-level Integrative Proteomics to Alzheimer's Disease PathwaysR01AG053987 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2016 to 2020
$2.2M
RNA splicing dysfunction in Alzheimer's diseaseR01AG047928 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2015 to 2019
$1.8M
Dissecting neuron-microglia-astrocyte interaction in AD pathogenesisR01AG068581 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN, ROSSOLL, WILFRIED · 2024 to 2024
$1.2M
NIA NIH HHS R01 AG047928NIA NIH HHS R01 AG053987NIA NIH HHS R01 AG068581NIA NIH HHS RF1 AG064909NIA NIH HHS RF1 AG068581NIA NIH HHS U19 AG069701NINDS NIH HHS U54 NS110435
6 · The paper itself

Abstract

Murine models of Alzheimer's disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. We comprehensively profiled age-dependent brain proteome and phosphoproteome (

Identifiers

PMID39484428
PMCPMC11527136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.