Evidence map›Paper›PMID 39484425›Full record

ArticlebioRxiv : the preprint server for biology2024

Cortical norepinephrine-astrocyte signaling critically mediates learned behavior.

Gabrielle T Drummond, Arundhati Natesan, Marco Celotto, Jennifer Shih, Prachi Ojha, Yuma Osako, Jiho Park, Grayson O Sipe, Kyle R Jenks, Vincent Breton-Provencher and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gabrielle T DrummondDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Arundhati NatesanDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Marco CelottoDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Jennifer ShihDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Prachi OjhaDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Yuma OsakoDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Jiho ParkDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Grayson O SipeDepartment of Biology, Eberly College of Science and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA.
Kyle R JenksDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Vincent Breton-ProvencherDepartment of Psychiatry and Neuroscience, CERVO Brain Research Center, Université Laval, Québec City, Québec, Canada.
Paul C SimpsonDepartment of Medicine and Research Service, San Francisco Veterans Affairs Medical Center and Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA.
Stefano PanzeriInstitute of Neural Information Processing, Center for Molecular Neurobiology (ZMNH), University Medical Center Hamburg-Eppendorf (UKE), 20251 Hamburg, Germany.
Mriganka SurDepartment of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Funding

MicroRNA mechanisms of Rett SyndromeR01MH085802 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2010 to 2025
$6.2M
Studying perceptual decision-making across cortex by combining population imaging, connectomics, and computational modelingR01NS108410 · NINDS · HARVARD MEDICAL SCHOOL · PI HARVEY, CHRISTOPHER D, LEE, WEI-CHUNG ALLEN · 2018 to 2022
$5.7M
Neuron-astrocyte mechanisms of norepinephrine in goal-directed learningR01MH133066 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2023 to 2026
$2.6M
Astrocyte-Neuron Circuits Underlying Cortical Mechanisms of Learned BehaviorR01NS130361 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MRIGANKA SUR · 2022 to 2026
$2.1M
Spatiotemporal dynamics of locus coeruleus circuits during learned behaviorR01MH126351 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SUR, MRIGANKA · 2021 to 2025
$2.1M
Spatiotemporal dynamics of locus coeruleus norepinephrine release in a learned behaviorF31MH129112 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DRUMMOND, GABRIELLE · 2022 to 2023
$82k
NIMH NIH HHS F31 MH129112NIMH NIH HHS R01 MH085802NIMH NIH HHS R01 MH126351NIMH NIH HHS R01 MH133066NINDS NIH HHS R01 NS108410NINDS NIH HHS R01 NS130361
6 · The paper itself

Abstract

Updating behavior based on feedback from the environment is a crucial means by which organisms learn and develop optimal behavioral strategies

Identifiers

PMID39484425
PMCPMC11527196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.