Evidence map›Paper›PMID 39484408›Full record

ArticlebioRxiv : the preprint server for biology2024

A genome-to-proteome atlas charts natural variants controlling proteome diversity and forecasts their fitness effects.

Christopher M Jakobson, Johannes Hartl, Pauline Trébulle, Michael Mülleder, Daniel F Jarosz, Markus Ralser

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Christopher M JakobsonDepasssrtment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-7594-7416
Johannes HartlBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-8470-5355
Pauline TrébulleCentre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4729-5032
Michael MüllederCore Facility High-Throughput Mass Spectrometry, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-9792-3861
Daniel F JaroszDepasssrtment of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-3497-5888
Markus RalserBerlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-9535-7413

Funding

Discovery of protein aggregates during vertebrate aging and neurodegenerationRF1AG057334 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE, JAROSZ, DANIEL · 2017 to 2017
$3.7M
Protein-based Molecular Memories in Gene Regulation, Disease, and DevelopmentDP2GM119140 · NIGMS · STANFORD UNIVERSITY · PI JAROSZ, DANIEL · 2015 to 2015
$2.4M
Mechanisms of Action of Natural Genetic VariationR01HG012366 · NHGRI · STANFORD UNIVERSITY · PI Daniel Jarosz · 2023 to 2026
$1.5M
Using self-templating proteins to spatiotemporally organize biochemistryF32GM125162 · NIGMS · STANFORD UNIVERSITY · PI JAKOBSON, CHRISTOPHER MATTHEW · 2017 to 2019
$179k
NHGRI NIH HHS R01 HG012366NIA NIH HHS RF1 AG057334NIGMS NIH HHS DP2 GM119140NIGMS NIH HHS F32 GM125162
6 · The paper itself

Abstract

Despite abundant genomic and phenotypic data across individuals and environments, the functional impact of most mutations on phenotype remains unclear. Here, we bridge this gap by linking genome to proteome in 800 meiotic progeny from an intercross between two closely related

Indexed as

adaptationgene expression evolutiongenotype-phenotype mappingomnigenic modelproteomicssystems geneticstransgressionvariant interpretation

Identifiers

PMID39484408
PMCPMC11526991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.